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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Widespread changes in surface temperature persistence under climate change
Jingyuan Li; David W. J. Thompson
Palabras clave: Multidisciplinary.
Pp. 425-430
Cardiopharyngeal deconstruction and ancestral tunicate sessility
Alfonso Ferrández-Roldán; Marc Fabregà-Torrus; Gaspar Sánchez-Serna; Enya Duran-Bello; Martí Joaquín-Lluís; Paula Bujosa; Marcos Plana-Carmona; Jordi Garcia-Fernàndez; Ricard Albalat; Cristian Cañestro
Palabras clave: Multidisciplinary.
Pp. 431-435
MC3R links nutritional state to childhood growth and the timing of puberty
B. Y. H. Lam; A. Williamson; S. Finer; F. R. Day; J. A. Tadross; A. Gonçalves Soares; K. Wade; P. Sweeney; M. N. Bedenbaugh; D. T. Porter; A. Melvin; K. L. J. Ellacott; R. N. Lippert; S. Buller; J. Rosmaninho-Salgado; G. K. C. Dowsett; K. E. Ridley; Z. Xu; I. Cimino; D. Rimmington; K. Rainbow; K. Duckett; S. Holmqvist; A. Khan; X. Dai; E. G. Bochukova; R. C. Trembath; H. C. Martin; A. P. Coll; D. H. Rowitch; N. J. Wareham; D. A. van Heel; N. Timpson; R. B. Simerly; K. K. Ong; R. D. Cone; C. Langenberg; J. R. B. Perry; G. S. Yeo; S. O’Rahilly;
Palabras clave: Multidisciplinary.
Pp. 436-441
Linking hippocampal multiplexed tuning, Hebbian plasticity and navigation
Jason J. Moore; Jesse D. Cushman; Lavanya Acharya; Briana Popeney; Mayank R. Mehta
Palabras clave: Multidisciplinary.
Pp. 442-448
The orbitofrontal cortex maps future navigational goals
Raunak Basu; Robert Gebauer; Tim Herfurth; Simon Kolb; Zahra Golipour; Tatjana Tchumatchenko; Hiroshi T. Ito
<jats:title>Abstract</jats:title><jats:p>Accurate navigation to a desired goal requires consecutive estimates of spatial relationships between the current position and future destination throughout the journey. Although neurons in the hippocampal formation can represent the position of an animal as well as its nearby trajectories<jats:sup>1–7</jats:sup>, their role in determining the destination of the animal has been questioned<jats:sup>8,9</jats:sup>. It is, thus, unclear whether the brain can possess a precise estimate of target location during active environmental exploration. Here we describe neurons in the rat orbitofrontal cortex (OFC) that form spatial representations persistently pointing to the subsequent goal destination of an animal throughout navigation. This destination coding emerges before the onset of navigation, without direct sensory access to a distal goal, and even predicts the incorrect destination of an animal at the beginning of an error trial. Goal representations in the OFC are maintained by destination-specific neural ensemble dynamics, and their brief perturbation at the onset of a journey led to a navigational error. These findings suggest that the OFC is part of the internal goal map of the brain, enabling animals to navigate precisely to a chosen destination that is beyond the range of sensory perception.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 449-452
Temporal controls over inter-areal cortical projection neuron fate diversity
Esther Klingler; Ugo Tomasello; Julien Prados; Justus M. Kebschull; Alessandro Contestabile; Gregorio L. Galiñanes; Sabine Fièvre; Antonio Santinha; Randall Platt; Daniel Huber; Alexandre Dayer; Camilla Bellone; Denis Jabaudon
Palabras clave: Multidisciplinary.
Pp. 453-457
Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians
Yuko Sato; Koji Atarashi; Damian R. Plichta; Yasumichi Arai; Satoshi Sasajima; Sean M. Kearney; Wataru Suda; Kozue Takeshita; Takahiro Sasaki; Shoki Okamoto; Ashwin N. Skelly; Yuki Okamura; Hera Vlamakis; Youxian Li; Takeshi Tanoue; Hajime Takei; Hiroshi Nittono; Seiko Narushima; Junichiro Irie; Hiroshi Itoh; Kyoji Moriya; Yuki Sugiura; Makoto Suematsu; Nobuko Moritoki; Shinsuke Shibata; Dan R. Littman; Michael A. Fischbach; Yoshifumi Uwamino; Takashi Inoue; Akira Honda; Masahira Hattori; Tsuyoshi Murai; Ramnik J. Xavier; Nobuyoshi Hirose; Kenya Honda
Palabras clave: Multidisciplinary.
Pp. 458-464
Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy
Rachel Yamin; Andrew T. Jones; Hans-Heinrich Hoffmann; Alexandra Schäfer; Kevin S. Kao; Rebecca L. Francis; Timothy P. Sheahan; Ralph S. Baric; Charles M. Rice; Jeffrey V. Ravetch; Stylianos Bournazos
Palabras clave: Multidisciplinary.
Pp. 465-470
B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity
Baihao Zhang; Alexis Vogelzang; Michio Miyajima; Yuki Sugiura; Yibo Wu; Kenji Chamoto; Rei Nakano; Ryusuke Hatae; Rosemary J. Menzies; Kazuhiro Sonomura; Nozomi Hojo; Taisaku Ogawa; Wakana Kobayashi; Yumi Tsutsui; Sachiko Yamamoto; Mikako Maruya; Seiko Narushima; Keiichiro Suzuki; Hiroshi Sugiya; Kosaku Murakami; Motomu Hashimoto; Hideki Ueno; Takashi Kobayashi; Katsuhiro Ito; Tomoko Hirano; Katsuyuki Shiroguchi; Fumihiko Matsuda; Makoto Suematsu; Tasuku Honjo; Sidonia Fagarasan
<jats:title>Abstract</jats:title><jats:p>Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu<jats:sup>1–3</jats:sup>. Here we identify the metabolite and neurotransmitter GABA as a candidate signalling molecule synthesized and secreted by activated B cells and plasma cells. We show that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages that secrete interleukin-10 and inhibit CD8<jats:sup>+</jats:sup> T cell killer function. In mice, B cell deficiency or B cell-specific inactivation of the GABA-generating enzyme GAD67 enhances anti-tumour responses. Our study reveals that, in addition to cytokines and membrane proteins, small metabolites derived from B-lineage cells have immunoregulatory functions, which may be pharmaceutical targets allowing fine-tuning of immune responses.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 471-476
Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Mark Yarmarkovich; Quinlen F. Marshall; John M. Warrington; Rasika Premaratne; Alvin Farrel; David Groff; Wei Li; Moreno di Marco; Erin Runbeck; Hau Truong; Jugmohit S. Toor; Sarvind Tripathi; Son Nguyen; Helena Shen; Tiffany Noel; Nicole L. Church; Amber Weiner; Nathan Kendsersky; Dan Martinez; Rebecca Weisberg; Molly Christie; Laurence Eisenlohr; Kristopher R. Bosse; Dimiter S. Dimitrov; Stefan Stevanovic; Nikolaos G. Sgourakis; Ben R. Kiefel; John M. Maris
<jats:title>Abstract</jats:title><jats:p>The majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented by individual human leukocyte antigen (HLA) allotypes<jats:sup>1</jats:sup>. However, most cancers have a modest mutational burden that is insufficient to generate responses using neoantigen-based therapies<jats:sup>2,3</jats:sup>. Neuroblastoma is a paediatric cancer that harbours few mutations and is instead driven by epigenetically deregulated transcriptional networks<jats:sup>4</jats:sup>. Here we show that the neuroblastoma immunopeptidome is enriched with peptides derived from proteins that are essential for tumourigenesis and focus on targeting the unmutated peptide QYNPIRTTF, discovered on HLA-A*24:02, which is derived from the neuroblastoma dependency gene and master transcriptional regulator <jats:italic>PHOX2B</jats:italic>. To target QYNPIRTTF, we developed peptide-centric chimeric antigen receptors (CARs) using a counter-panning strategy with predicted potentially cross-reactive peptides. We further hypothesized that peptide-centric CARs could recognize peptides on additional HLA allotypes when presented in a similar manner. Informed by computational modelling, we showed that PHOX2B peptide-centric CARs also recognize QYNPIRTTF presented by HLA-A*23:01 and the highly divergent HLA-B*14:02. Finally, we demonstrated potent and specific killing of neuroblastoma cells expressing these HLAs in vitro and complete tumour regression in mice. These data suggest that peptide-centric CARs have the potential to vastly expand the pool of immunotherapeutic targets to include non-immunogenic intracellular oncoproteins and widen the population of patients who would benefit from such therapy by breaking conventional HLA restriction.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 477-484