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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Human neural tube morphogenesis in vitro by geometric constraints
Eyal Karzbrun
; Aimal H. Khankhel; Heitor C. Megale; Stella M. K. Glasauer; Yofiel Wyle; George Britton; Aryeh Warmflash; Kenneth S. Kosik; Eric D. Siggia; Boris I. Shraiman; Sebastian J. Streichan
Palabras clave: Multidisciplinary.
Pp. 268-272
Cell surface and intracellular auxin signalling for H+ fluxes in root growth
Lanxin Li; Inge Verstraeten; Mark Roosjen; Koji Takahashi; Lesia Rodriguez; Jack Merrin; Jian Chen; Lana Shabala; Wouter Smet; Hong Ren; Steffen Vanneste; Sergey Shabala; Bert De Rybel; Dolf Weijers; Toshinori Kinoshita; William M. Gray; Jiří Friml
Palabras clave: Multidisciplinary.
Pp. 273-277
TMK-based cell-surface auxin signalling activates cell-wall acidification
Wenwei Lin; Xiang Zhou; Wenxin Tang; Koji Takahashi; Xue Pan; Jiawei Dai; Hong Ren; Xiaoyue Zhu; Songqin Pan; Haiyan Zheng; William M. Gray; Tongda Xu; Toshinori Kinoshita; Zhenbiao Yang
<jats:title>Abstract</jats:title><jats:p>The phytohormone auxin controls many processes in plants, at least in part through its regulation of cell expansion<jats:sup>1</jats:sup>. The acid growth hypothesis has been proposed to explain auxin-stimulated cell expansion for five decades, but the mechanism that underlies auxin-induced cell-wall acidification is poorly characterized. Auxin induces the phosphorylation and activation of the plasma membrane H<jats:sup>+</jats:sup>-ATPase that pumps protons into the apoplast<jats:sup>2</jats:sup>, yet how auxin activates its phosphorylation remains unclear. Here we show that the transmembrane kinase (TMK) auxin-signalling proteins interact with plasma membrane H<jats:sup>+</jats:sup>-ATPases, inducing their phosphorylation, and thereby promoting cell-wall acidification and hypocotyl cell elongation in <jats:italic>Arabidopsis</jats:italic>. Auxin induced interactions between TMKs and H<jats:sup>+</jats:sup>-ATPases in the plasma membrane within seconds, as well as TMK-dependent phosphorylation of the penultimate threonine residue on the H+-ATPases. Our genetic, biochemical and molecular evidence demonstrates that TMKs directly phosphorylate plasma membrane H<jats:sup>+</jats:sup>-ATPase and are required for auxin-induced H<jats:sup>+</jats:sup>-ATPase activation, apoplastic acidification and cell expansion. Thus, our findings reveal a crucial connection between auxin and plasma membrane H<jats:sup>+</jats:sup>-ATPase activation in regulating apoplastic pH changes and cell expansion through TMK-based cell surface auxin signalling.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 278-282
Virus-induced senescence is a driver and therapeutic target in COVID-19
Soyoung Lee; Yong Yu; Jakob Trimpert; Fahad Benthani; Mario Mairhofer; Paulina Richter-Pechanska; Emanuel Wyler; Dimitri Belenki; Sabine Kaltenbrunner; Maria Pammer; Lea Kausche; Theresa C. Firsching; Kristina Dietert; Michael Schotsaert; Carles Martínez-Romero; Gagandeep Singh; Séverine Kunz; Daniela Niemeyer; Riad Ghanem; Helmut J. F. Salzer; Christian Paar; Michael Mülleder; Melissa Uccellini; Edward G. Michaelis; Amjad Khan; Andrea Lau; Martin Schönlein; Anna Habringer; Josef Tomasits; Julia M. Adler; Susanne Kimeswenger; Achim D. Gruber; Wolfram Hoetzenecker; Herta Steinkellner; Bettina Purfürst; Reinhard Motz; Francesco Di Pierro; Bernd Lamprecht; Nikolaus Osterrieder; Markus Landthaler; Christian Drosten; Adolfo García-Sastre; Rupert Langer; Markus Ralser; Roland Eils; Maurice Reimann; Dorothy N. Y. Fan; Clemens A. Schmitt
Palabras clave: Multidisciplinary.
Pp. 283-289
Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11
Zilin Li; Wang Liu; Jiaqi Fu; Sen Cheng; Yue Xu; Zhiqiang Wang; Xiaofan Liu; Xuyan Shi; Yaxin Liu; Xiangbing Qi; Xiaoyun Liu; Jingjin Ding; Feng Shao
Palabras clave: Multidisciplinary.
Pp. 290-295
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes
Omer Keinan; Joseph M. Valentine; Haopeng Xiao; Sushil K. Mahata; Shannon M. Reilly; Mohammad Abu-Odeh; Julia H. Deluca; Benyamin Dadpey; Leslie Cho; Austin Pan; Ruth T. Yu; Yang Dai; Christopher Liddle; Michael Downes; Ronald M. Evans; Aldons J. Lusis; Markku Laakso; Edward T. Chouchani; Mikael Rydén; Alan R. Saltiel
Palabras clave: Multidisciplinary.
Pp. 296-301
Low glycaemic diets alter lipid metabolism to influence tumour growth
Evan C. Lien; Anna M. Westermark; Yin Zhang; Chen Yuan; Zhaoqi Li; Allison N. Lau; Kiera M. Sapp; Brian M. Wolpin; Matthew G. Vander Heiden
Palabras clave: Multidisciplinary.
Pp. 302-307
eccDNAs are apoptotic products with high innate immunostimulatory activity
Yuangao Wang; Meng Wang; Mohamed Nadhir Djekidel; Huan Chen; Di Liu; Frederick W. Alt; Yi Zhang
Palabras clave: Multidisciplinary.
Pp. 308-314
The structure of neurofibromin isoform 2 reveals different functional states
Andreas Naschberger; Rozbeh Baradaran; Bernhard Rupp; Marta Carroni
<jats:title>Abstract</jats:title><jats:p>The autosomal dominant monogenetic disease neurofibromatosis type 1 (NF1) affects approximately one in 3,000 individuals and is caused by mutations in the <jats:italic>NF1</jats:italic> tumour suppressor gene, leading to dysfunction in the protein neurofibromin (Nf1)<jats:sup>1,2</jats:sup>. As a GTPase-activating protein, a key function of Nf1 is repression of the Ras oncogene signalling cascade. We determined the human Nf1 dimer structure at an overall resolution of 3.3 Å. The cryo-electron microscopy structure reveals domain organization and structural details of the Nf1 exon 23a splicing<jats:sup>3</jats:sup> isoform 2 in a closed, self-inhibited, Zn-stabilized state and an open state. In the closed conformation, HEAT/ARM core domains shield the GTPase-activating protein-related domain (GRD) so that Ras binding is sterically inhibited. In a distinctly different, open conformation of one protomer, a large-scale movement of the GRD occurs, which is necessary to access Ras, whereas Sec14-PH reorients to allow interaction with the cellular membrane<jats:sup>4</jats:sup>. Zn incubation of Nf1 leads to reduced Ras-GAP activity with both protomers in the self-inhibited, closed conformation stabilized by a Zn binding site between the N-HEAT/ARM domain and the GRD–Sec14-PH linker. The transition between closed, self-inhibited states of Nf1 and open states provides guidance for targeted studies deciphering the complex molecular mechanism behind the widespread neurofibromatosis syndrome and Nf1 dysfunction in carcinogenesis.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 315-319
Dispatched uses Na+ flux to power release of lipid-modified Hedgehog
Qianqian Wang; Daniel E. Asarnow; Ke Ding; Randall K. Mann; Jason Hatakeyama; Yunxiao Zhang; Yong Ma; Yifan Cheng; Philip A. Beachy
Palabras clave: Multidisciplinary.
Pp. 320-324