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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
The mutational landscape of human somatic and germline cells
Luiza Moore
; Alex Cagan; Tim H. H. Coorens; Matthew D. C. Neville; Rashesh Sanghvi; Mathijs A. Sanders; Thomas R. W. Oliver; Daniel Leongamornlert; Peter Ellis; Ayesha Noorani; Thomas J. Mitchell; Timothy M. Butler; Yvette Hooks; Anne Y. Warren; Mette Jorgensen; Kevin J. Dawson; Andrew Menzies; Laura O’Neill; Calli Latimer; Mabel Teng; Ruben van Boxtel; Christine A. Iacobuzio-Donahue; Inigo Martincorena; Rakesh Heer; Peter J. Campbell; Rebecca C. Fitzgerald; Michael R. Stratton; Raheleh Rahbari
Palabras clave: Multidisciplinary.
Pp. 381-386
Extensive phylogenies of human development inferred from somatic mutations
Tim H. H. Coorens; Luiza Moore; Philip S. Robinson; Rashesh Sanghvi; Joseph Christopher; James Hewinson; Moritz J. Przybilla; Andrew R. J. Lawson; Michael Spencer Chapman; Alex Cagan; Thomas R. W. Oliver; Matthew D. C. Neville; Yvette Hooks; Ayesha Noorani; Thomas J. Mitchell; Rebecca C. Fitzgerald; Peter J. Campbell; Iñigo Martincorena; Raheleh Rahbari; Michael R. Stratton
Palabras clave: Multidisciplinary.
Pp. 387-392
Clonal dynamics in early human embryogenesis inferred from somatic mutation
Seongyeol Park; Nanda Maya Mali; Ryul Kim; Jeong-Woo Choi; Junehawk Lee; Joonoh Lim; Jung Min Park; Jung Woo Park; Donghyun Kim; Taewoo Kim; Kijong Yi; June Hyug Choi; Seong Gyu Kwon; Joo Hee Hong; Jeonghwan Youk; Yohan An; Su Yeon Kim; Soo A Oh; Youngoh Kwon; Dongwan Hong; Moonkyu Kim; Dong Sun Kim; Ji Young Park; Ji Won Oh; Young Seok Ju
Palabras clave: Multidisciplinary.
Pp. 393-397
A body map of somatic mutagenesis in morphologically normal human tissues
Ruoyan Li; Lin Di; Jie Li; Wenyi Fan; Yachen Liu; Wenjia Guo; Weiling Liu; Lu Liu; Qiong Li; Liping Chen; Yamei Chen; Chuanwang Miao; Hongjin Liu; Yuqian Wang; Yuling Ma; Deshu Xu; Dongxin Lin; Yanyi Huang; Jianbin Wang; Fan Bai; Chen Wu
Palabras clave: Multidisciplinary.
Pp. 398-403
Behavioural nudges increase COVID-19 vaccinations
Hengchen Dai; Silvia Saccardo; Maria A. Han; Lily Roh; Naveen Raja; Sitaram Vangala; Hardikkumar Modi; Shital Pandya; Michael Sloyan; Daniel M. Croymans
<jats:title>Abstract</jats:title><jats:p>Enhancing vaccine uptake is a critical public health challenge<jats:sup>1</jats:sup>. Overcoming vaccine hesitancy<jats:sup>2,3</jats:sup> and failure to follow through on vaccination intentions<jats:sup>3</jats:sup> requires effective communication strategies<jats:sup>3,4</jats:sup>. Here we present two sequential randomized controlled trials to test the effect of behavioural interventions on the uptake of COVID-19 vaccines. We designed text-based reminders that make vaccination salient and easy, and delivered them to participants drawn from a healthcare system one day (first randomized controlled trial) (<jats:italic>n</jats:italic>Â =Â 93,354Â participants; clinicaltrials number NCT04800965) and eight days (second randomized controlled trial) (<jats:italic>n</jats:italic>Â =Â 67,092 individuals; clinicaltrials number NCT04801524) after they received a notification of vaccine eligibility. The first reminder boosted appointment and vaccination rates within the healthcare system by 6.07 (84%) and 3.57 (26%) percentage points, respectively; the second reminder increased those outcomes by 1.65 and 1.06 percentage points, respectively. The first reminder had a greater effect when it was designed to make participants feel ownership of the vaccine dose. However, we found no evidence that combining the first reminder with a video-based information intervention designed to address vaccine hesitancy heightened its effect. We performed online studies (<jats:italic>n</jats:italic>Â =Â 3,181Â participants) to examine vaccination intentions, which revealed patterns that diverged from those of the first randomized controlled trial; this underscores the importance of pilot-testing interventions in the field. Our findings inform the design of behavioural nudges for promoting health decisions<jats:sup>5</jats:sup>, and highlight the value of making vaccination easy and inducing feelings of ownership over vaccines.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 404-409
Neuro-mesenchymal units control ILC2 and obesity via a brain–adipose circuit
Filipa Cardoso; Roel G. J. Klein Wolterink; Cristina Godinho-Silva; Rita G. Domingues; Hélder Ribeiro; Joaquim Alves da Silva; Inês Mahú; Ana I. Domingos; Henrique Veiga-Fernandes
Palabras clave: Multidisciplinary.
Pp. 410-414
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
SangJoon Lee; Rajendra Karki; Yaqiu Wang; Lam Nhat Nguyen; Ravi C. Kalathur; Thirumala-Devi Kanneganti
Palabras clave: Multidisciplinary.
Pp. 415-419
The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway
Robert S. Banh; Esther S. Kim; Quentin Spillier; Douglas E. Biancur; Keisuke Yamamoto; Albert S. W. Sohn; Guangbin Shi; Drew R. Jones; Alec C. Kimmelman; Michael E. Pacold
Palabras clave: Multidisciplinary.
Pp. 420-425
RecA finds homologous DNA by reduced dimensionality search
Jakub Wiktor; Arvid H. Gynnå; Prune Leroy; Jimmy Larsson; Giovanna Coceano; Ilaria Testa; Johan Elf
<jats:title>Abstract</jats:title><jats:p>Homologous recombination is essential for the accurate repair of double-stranded DNA breaks (DSBs)<jats:sup>1</jats:sup>. Initially, the RecBCD complex<jats:sup>2</jats:sup> resects the ends of the DSB into 3′ single-stranded DNA on which a RecA filament assembles<jats:sup>3</jats:sup>. Next, the filament locates the homologous repair template on the sister chromosome<jats:sup>4</jats:sup>. Here we directly visualize the repair of DSBs in single cells, using high-throughput microfluidics and fluorescence microscopy. We find that, in <jats:italic>Escherichia coli</jats:italic>, repair of DSBs between segregated sister loci is completed in 15 ± 5 min (mean ± s.d.) with minimal fitness loss. We further show that the search takes less than 9 ± 3 min (mean ± s.d) and is mediated by a thin, highly dynamic RecA filament that stretches throughout the cell. We propose that the architecture of the RecA filament effectively reduces search dimensionality. This model predicts a search time that is consistent with our measurement and is corroborated by the observation that the search time does not depend on the length of the cell or the amount of DNA. Given the abundance of RecA homologues<jats:sup>5</jats:sup>, we believe this model to be widely conserved across living organisms.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 426-429
Structure of Geobacter pili reveals secretory rather than nanowire behaviour
Yangqi Gu; Vishok Srikanth; Aldo I. Salazar-Morales; Ruchi Jain; J. Patrick O’Brien; Sophia M. Yi; Rajesh Kumar Soni; Fadel A. Samatey; Sibel Ebru Yalcin; Nikhil S. Malvankar
Palabras clave: Multidisciplinary.
Pp. 430-434