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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
A metabolic function of the hippocampal sharp wave-ripple
David Tingley; Kathryn McClain; Ekin Kaya
; Jordan Carpenter; György Buzsáki
Palabras clave: Multidisciplinary.
Pp. 82-86
Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche
David Willnow; Uwe Benary; Anca Margineanu; Maria Lillina Vignola; Fabian Konrath; Igor M. Pongrac; Zahra Karimaddini; Alessandra Vigilante; Jana Wolf; Francesca M. Spagnoli
Palabras clave: Multidisciplinary.
Pp. 87-91
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans
Dimitrios Tsiantoulas; Mahya Eslami; Georg Obermayer; Marc Clement; Diede Smeets; Florian J. Mayer; Máté G. Kiss; Lennart Enders; Juliane Weißer; Laura Göderle; Jordi Lambert; Florian Frommlet; André Mueller; Tim Hendrikx; Maria Ozsvar-Kozma; Florentina Porsch; Laure Willen; Taras Afonyushkin; Jane E. Murphy; Per Fogelstrand; Olivier Donzé; Gerard Pasterkamp; Matthias Hoke; Stefan Kubicek; Helle F. Jørgensen; Nicolas Danchin; Tabassome Simon; Hubert Scharnagl; Winfried März; Jan Borén; Henry Hess; Ziad Mallat; Pascal Schneider; Christoph J. Binder
Palabras clave: Multidisciplinary.
Pp. 92-96
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape
Tyler N. Starr; Nadine Czudnochowski; Zhuoming Liu; Fabrizia Zatta; Young-Jun Park; Amin Addetia; Dora Pinto; Martina Beltramello; Patrick Hernandez; Allison J. Greaney; Roberta Marzi; William G. Glass; Ivy Zhang; Adam S. Dingens; John E. Bowen; M. Alejandra Tortorici; Alexandra C. Walls; Jason A. Wojcechowskyj; Anna De Marco; Laura E. Rosen; Jiayi Zhou; Martin Montiel-Ruiz; Hannah Kaiser; Josh R. Dillen; Heather Tucker; Jessica Bassi; Chiara Silacci-Fregni; Michael P. Housley; Julia di Iulio; Gloria Lombardo; Maria Agostini; Nicole Sprugasci; Katja Culap; Stefano Jaconi; Marcel Meury; Exequiel Dellota Jr; Rana Abdelnabi; Shi-Yan Caroline Foo; Elisabetta Cameroni; Spencer Stumpf; Tristan I. Croll; Jay C. Nix; Colin Havenar-Daughton; Luca Piccoli; Fabio Benigni; Johan Neyts; Amalio Telenti; Florian A. Lempp; Matteo S. Pizzuto; John D. Chodera; Christy M. Hebner; Herbert W. Virgin; Sean P. J. Whelan; David Veesler; Davide Corti; Jesse D. Bloom; Gyorgy Snell
Palabras clave: Multidisciplinary.
Pp. 97-102
Broad sarbecovirus neutralization by a human monoclonal antibody
M. Alejandra Tortorici; Nadine Czudnochowski; Tyler N. Starr; Roberta Marzi; Alexandra C. Walls; Fabrizia Zatta; John E. Bowen; Stefano Jaconi; Julia Di Iulio; Zhaoqian Wang; Anna De Marco; Samantha K. Zepeda; Dora Pinto; Zhuoming Liu; Martina Beltramello; Istvan Bartha; Michael P. Housley; Florian A. Lempp; Laura E. Rosen; Exequiel Dellota; Hannah Kaiser; Martin Montiel-Ruiz; Jiayi Zhou; Amin Addetia; Barbara Guarino; Katja Culap; Nicole Sprugasci; Christian Saliba; Eneida Vetti; Isabella Giacchetto-Sasselli; Chiara Silacci Fregni; Rana Abdelnabi; Shi-Yan Caroline Foo; Colin Havenar-Daughton; Michael A. Schmid; Fabio Benigni; Elisabetta Cameroni; Johan Neyts; Amalio Telenti; Herbert W. Virgin; Sean P. J. Whelan; Gyorgy Snell; Jesse D. Bloom; Davide Corti; David Veesler; Matteo Samuele Pizzuto
Palabras clave: Multidisciplinary.
Pp. 103-108
cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila
Kailey M. Slavik; Benjamin R. Morehouse; Adelyn E. Ragucci; Wen Zhou; Xianlong Ai; Yuqiang Chen; Lihua Li; Ziming Wei; Heike Bähre; Martin König; Roland Seifert; Amy S. Y. Lee; Hua Cai; Jean-Luc Imler; Philip J. Kranzusch
<jats:title>Abstract</jats:title><jats:p>Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger cG[2′–5′]pA[3′–5′]p (2′3′-cGAMP) and controls activation of innate immunity in mammalian cells<jats:sup>1–5</jats:sup>. Animal genomes typically encode multiple proteins with predicted homology to cGAS<jats:sup>6–10</jats:sup>, but the function of these uncharacterized enzymes is unknown. Here we show that cGAS-like receptors (cGLRs) are innate immune sensors that are capable of recognizing divergent molecular patterns and catalysing synthesis of distinct nucleotide second messenger signals. Crystal structures of human and insect cGLRs reveal a nucleotidyltransferase signalling core shared with cGAS and a diversified primary ligand-binding surface modified with notable insertions and deletions. We demonstrate that surface remodelling of cGLRs enables altered ligand specificity and used a forward biochemical screen to identify cGLR1 as a double-stranded RNA sensor in the model organism <jats:italic>Drosophila melanogaster</jats:italic>. We show that RNA recognition activates <jats:italic>Drosophila</jats:italic> cGLR1 to synthesize the novel product cG[3′–5′]pA[2′–5′]p (3′2′-cGAMP). A crystal structure of <jats:italic>Drosophila</jats:italic> stimulator of interferon genes (dSTING) in complex with 3′2′-cGAMP explains selective isomer recognition, and 3′2′-cGAMP induces an enhanced antiviral state in vivo that protects from viral infection. Similar to radiation of Toll-like receptors in pathogen immunity, our results establish cGLRs as a diverse family of metazoan pattern recognition receptors.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 109-113
Two cGAS-like receptors induce antiviral immunity in Drosophila
Andreas Holleufer; Kasper Grønbjerg Winther; Hans Henrik Gad; Xianlong Ai; Yuqiang Chen; Lihua Li; Ziming Wei; Huimin Deng; Jiyong Liu; Ninna Ahlmann Frederiksen; Bine Simonsen; Line Lykke Andersen; Karin Kleigrewe; Louise Dalskov; Andreas Pichlmair; Hua Cai; Jean-Luc Imler; Rune Hartmann
Palabras clave: Multidisciplinary.
Pp. 114-118
A clinically applicable integrative molecular classification of meningiomas
Farshad Nassiri; Jeff Liu; Vikas Patil; Yasin Mamatjan; Justin Z. Wang; Rupert Hugh-White; Andrew M. Macklin; Shahbaz Khan; Olivia Singh; Shirin Karimi; Rosario I. Corona; Lydia Y. Liu; Caroline Y. Chen; Ankur Chakravarthy; Qingxia Wei; Bharati Mehani; Suganth Suppiah; Andrew Gao; Adriana M. Workewych; Ghazaleh Tabatabai; Paul C. Boutros; Gary D. Bader; Daniel D. de Carvalho; Thomas Kislinger; Kenneth Aldape; Gelareh Zadeh
Palabras clave: Multidisciplinary.
Pp. 119-125
The structural basis of odorant recognition in insect olfactory receptors
Josefina del Mármol; Mackenzie A. Yedlin; Vanessa Ruta
<jats:title>Abstract</jats:title><jats:p>Olfactory systems must detect and discriminate amongst an enormous variety of odorants<jats:sup>1</jats:sup>. To contend with this challenge, diverse species have converged on a common strategy in which odorant identity is encoded through the combinatorial activation of large families of olfactory receptors<jats:sup>1–3</jats:sup>, thus allowing a finite number of receptors to detect a vast chemical world. Here we offer structural and mechanistic insight into how an individual olfactory receptor can flexibly recognize diverse odorants. We show that the olfactory receptor <jats:italic>Mh</jats:italic>OR5 from the jumping bristletail<jats:sup>4</jats:sup><jats:italic>Machilis hrabei</jats:italic> assembles as a homotetrameric odorant-gated ion channel with broad chemical tuning. Using cryo-electron microscopy, we elucidated the structure of <jats:italic>Mh</jats:italic>OR5 in multiple gating states, alone and in complex with two of its agonists—the odorant eugenol and the insect repellent DEET. Both ligands are recognized through distributed hydrophobic interactions within the same geometrically simple binding pocket located in the transmembrane region of each subunit, suggesting a structural logic for the promiscuous chemical sensitivity of this receptor. Mutation of individual residues lining the binding pocket predictably altered the sensitivity of <jats:italic>Mh</jats:italic>OR5 to eugenol and DEET and broadly reconfigured the receptor’s tuning. Together, our data support a model in which diverse odorants share the same structural determinants for binding, shedding light on the molecular recognition mechanisms that ultimately endow the olfactory system with its immense discriminatory capacity.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 126-131
DAXX represents a new type of protein-folding enabler
Liangqian Huang; Trisha Agrawal; Guixin Zhu; Sixiang Yu; Liming Tao; JiaBei Lin; Ronen Marmorstein; James Shorter; Xiaolu Yang
Palabras clave: Multidisciplinary.
Pp. 132-137