Catálogo de publicaciones - revistas
Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Operationalizing the net-negative carbon economy
Johannes Bednar
; Michael Obersteiner; Artem Baklanov; Marcus Thomson; Fabian Wagner; Oliver Geden; Myles Allen; Jim W. Hall
Palabras clave: Multidisciplinary.
Pp. 377-383
The Montreal Protocol protects the terrestrial carbon sink
Paul J. Young; Anna B. Harper; Chris Huntingford; Nigel D. Paul; Olaf Morgenstern; Paul A. Newman; Luke D. Oman; Sasha Madronich; Rolando R. Garcia
Palabras clave: Multidisciplinary.
Pp. 384-388
Agrochemicals interact synergistically to increase bee mortality
Harry Siviter; Emily J. Bailes; Callum D. Martin; Thomas R. Oliver; Julia Koricheva; Ellouise Leadbeater; Mark J. F. Brown
Palabras clave: Multidisciplinary.
Pp. 389-392
Genetic insights into biological mechanisms governing human ovarian ageing
Katherine S. Ruth; Felix R. Day; Jazib Hussain; Ana Martínez-Marchal; Catherine E. Aiken; Ajuna Azad; Deborah J. Thompson; Lucie Knoblochova; Hironori Abe; Jane L. Tarry-Adkins; Javier Martin Gonzalez; Pierre Fontanillas; Annique Claringbould; Olivier B. Bakker; Patrick Sulem; Robin G. Walters; Chikashi Terao; Sandra Turon; Momoko Horikoshi; Kuang Lin; N. Charlotte Onland-Moret; Aditya Sankar; Emil Peter Thrane Hertz; Pascal N. Timshel; Vallari Shukla; Rehannah Borup; Kristina W. Olsen; Paula Aguilera; Mònica Ferrer-Roda; Yan Huang; Stasa Stankovic; Paul R. H. J. Timmers; Thomas U. Ahearn; Behrooz Z. Alizadeh; Elnaz Naderi; Irene L. Andrulis; Alice M. Arnold; Kristan J. Aronson; Annelie Augustinsson; Stefania Bandinelli; Caterina M. Barbieri; Robin N. Beaumont; Heiko Becher; Matthias W. Beckmann; Stefania Benonisdottir; Sven Bergmann; Murielle Bochud; Eric Boerwinkle; Stig E. Bojesen; Manjeet K. Bolla; Dorret I. Boomsma; Nicholas Bowker; Jennifer A. Brody; Linda Broer; Julie E. Buring; Archie Campbell; Harry Campbell; Jose E. Castelao; Eulalia Catamo; Stephen J. Chanock; Georgia Chenevix-Trench; Marina Ciullo; Tanguy Corre; Fergus J. Couch; Angela Cox; Laura Crisponi; Simon S. Cross; Francesco Cucca; Kamila Czene; George Davey Smith; Eco J. C. N. de Geus; Renée de Mutsert; Immaculata De Vivo; Ellen W. Demerath; Joe Dennis; Alison M. Dunning; Miriam Dwek; Mikael Eriksson; Tõnu Esko; Peter A. Fasching; Jessica D. Faul; Luigi Ferrucci; Nora Franceschini; Timothy M. Frayling; Manuela Gago-Dominguez; Massimo Mezzavilla; Montserrat García-Closas; Christian Gieger; Graham G. Giles; Harald Grallert; Daniel F. Gudbjartsson; Vilmundur Gudnason; Pascal Guénel; Christopher A. Haiman; Niclas Håkansson; Per Hall; Caroline Hayward; Chunyan He; Wei He; Gerardo Heiss; Miya K. Høffding; John L. Hopper; Jouke J. Hottenga; Frank Hu; David Hunter; Mohammad A. Ikram; Rebecca D. Jackson; Micaella D. R. Joaquim; Esther M. John; Peter K. Joshi; David Karasik; Sharon L. R. Kardia; Christiana Kartsonaki; Robert Karlsson; Cari M. Kitahara; Ivana Kolcic; Charles Kooperberg; Peter Kraft; Allison W. Kurian; Zoltan Kutalik; Martina La Bianca; Genevieve LaChance; Claudia Langenberg; Lenore J. Launer; Joop S. E. Laven; Deborah A. Lawlor; Loic Le Marchand; Jingmei Li; Annika Lindblom; Sara Lindstrom; Tricia Lindstrom; Martha Linet; YongMei Liu; Simin Liu; Jian’an Luan; Reedik Mägi; Patrik K. E. Magnusson; Massimo Mangino; Arto Mannermaa; Brumat Marco; Jonathan Marten; Nicholas G. Martin; Hamdi Mbarek; Barbara McKnight; Sarah E. Medland; Christa Meisinger; Thomas Meitinger; Cristina Menni; Andres Metspalu; Lili Milani; Roger L. Milne; Grant W. Montgomery; Dennis O. Mook-Kanamori; Antonella Mulas; Anna M. Mulligan; Alison Murray; Mike A. Nalls; Anne Newman; Raymond Noordam; Teresa Nutile; Dale R. Nyholt; Andrew F. Olshan; Håkan Olsson; Jodie N. Painter; Alpa V. Patel; Nancy L. Pedersen; Natalia Perjakova; Annette Peters; Ulrike Peters; Paul D. P. Pharoah; Ozren Polasek; Eleonora Porcu; Bruce M. Psaty; Iffat Rahman; Gad Rennert; Hedy S. Rennert; Paul M. Ridker; Susan M. Ring; Antonietta Robino; Lynda M. Rose; Frits R. Rosendaal; Jacques Rossouw; Igor Rudan; Rico Rueedi; Daniela Ruggiero; Cinzia F. Sala; Emmanouil Saloustros; Dale P. Sandler; Serena Sanna; Elinor J. Sawyer; Chloé Sarnowski; David Schlessinger; Marjanka K. Schmidt; Minouk J. Schoemaker; Katharina E. Schraut; Christopher Scott; Saleh Shekari; Amruta Shrikhande; Albert V. Smith; Blair H. Smith; Jennifer A. Smith; Rossella Sorice; Melissa C. Southey; Tim D. Spector; John J. Spinelli; Meir Stampfer; Doris Stöckl; Joyce B. J. van Meurs; Konstantin Strauch; Unnur Styrkarsdottir; Anthony J. Swerdlow; Toshiko Tanaka; Lauren R. Teras; Alexander Teumer; Unnur Þorsteinsdottir; Nicholas J. Timpson; Daniela Toniolo; Michela Traglia; Melissa A. Troester; Thérèse Truong; Jessica Tyrrell; André G. Uitterlinden; Sheila Ulivi; Celine M. Vachon; Veronique Vitart; Uwe Völker; Peter Vollenweider; Henry Völzke; Qin Wang; Nicholas J. Wareham; Clarice R. Weinberg; David R. Weir; Amber N. Wilcox; Ko Willems van Dijk; Gonneke Willemsen; James F. Wilson; Bruce H. R. Wolffenbuttel; Alicja Wolk; Andrew R. Wood; Wei Zhao; Marek Zygmunt; Zhengming Chen; Liming Li; Lude Franke; Stephen Burgess; Patrick Deelen; Tune H. Pers; Marie Louise Grøndahl; Claus Yding Andersen; Anna Pujol; Andres J. Lopez-Contreras; Jeremy A. Daniel; Kari Stefansson; Jenny Chang-Claude; Yvonne T. van der Schouw; Kathryn L. Lunetta; Daniel I. Chasman; Douglas F. Easton; Jenny A. Visser; Susan E. Ozanne; Satoshi H. Namekawa; Petr Solc; Joanne M. Murabito; Ken K. Ong; Eva R. Hoffmann; Anna Murray; Ignasi Roig; John R. B. Perry; ; ; ; ; ; ; ;
Palabras clave: Multidisciplinary.
Pp. 393-397
Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma
Davide G. Berta; Heli Kuisma; Niko Välimäki; Maritta Räisänen; Maija Jäntti; Annukka Pasanen; Auli Karhu; Jaana Kaukomaa; Aurora Taira; Tatiana Cajuso; Sanna Nieminen; Rosa-Maria Penttinen; Saija Ahonen; Rainer Lehtonen; Miika Mehine; Pia Vahteristo; Jyrki Jalkanen; Biswajyoti Sahu; Janne Ravantti; Netta Mäkinen; Kristiina Rajamäki; Kimmo Palin; Jussi Taipale; Oskari Heikinheimo; Ralf Bützow; Eevi Kaasinen; Lauri A. Aaltonen
Palabras clave: Multidisciplinary.
Pp. 398-403
Locally ordered representation of 3D space in the entorhinal cortex
Gily Ginosar; Johnatan Aljadeff; Yoram Burak; Haim Sompolinsky; Liora Las; Nachum Ulanovsky
Palabras clave: Multidisciplinary.
Pp. 404-409
Systems vaccinology of the BNT162b2 mRNA vaccine in humans
Prabhu S. Arunachalam; Madeleine K. D. Scott; Thomas Hagan; Chunfeng Li; Yupeng Feng; Florian Wimmers; Lilit Grigoryan; Meera Trisal; Venkata Viswanadh Edara; Lilin Lai; Sarah Esther Chang; Allan Feng; Shaurya Dhingra; Mihir Shah; Alexandra S. Lee; Sharon Chinthrajah; Sayantani B. Sindher; Vamsee Mallajosyula; Fei Gao; Natalia Sigal; Sangeeta Kowli; Sheena Gupta; Kathryn Pellegrini; Gregory Tharp; Sofia Maysel-Auslender; Sydney Hamilton; Hadj Aoued; Kevin Hrusovsky; Mark Roskey; Steven E. Bosinger; Holden T. Maecker; Scott D. Boyd; Mark M. Davis; Paul J. Utz; Mehul S. Suthar; Purvesh Khatri; Kari C. Nadeau; Bali Pulendran
Palabras clave: Multidisciplinary.
Pp. 410-416
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
Dami A. Collier; Isabella A. T. M. Ferreira; Prasanti Kotagiri; Rawlings P. Datir; Eleanor Y. Lim; Emma Touizer; Bo Meng; Adam Abdullahi; Stephen Baker; Gordon Dougan; Christoph Hess; Nathalie Kingston; Paul J. Lehner; Paul A. Lyons; Nicholas J. Matheson; Willem H. Owehand; Caroline Saunders; Charlotte Summers; James E. D. Thaventhiran; Mark Toshner; Michael P. Weekes; Patrick Maxwell; Ashley Shaw; Ashlea Bucke; Jo Calder; Laura Canna; Jason Domingo; Anne Elmer; Stewart Fuller; Julie Harris; Sarah Hewitt; Jane Kennet; Sherly Jose; Jenny Kourampa; Anne Meadows; Criona O’Brien; Jane Price; Cherry Publico; Rebecca Rastall; Carla Ribeiro; Jane Rowlands; Valentina Ruffolo; Hugo Tordesillas; Ben Bullman; Benjamin J. Dunmore; Stuart Fawke; Stefan Gräf; Josh Hodgson; Christopher Huang; Kelvin Hunter; Emma Jones; Ekaterina Legchenko; Cecilia Matara; Jennifer Martin; Federica Mescia; Ciara O’Donnell; Linda Pointon; Nicole Pond; Joy Shih; Rachel Sutcliffe; Tobias Tilly; Carmen Treacy; Zhen Tong; Jennifer Wood; Marta Wylot; Laura Bergamaschi; Ariana Betancourt; Georgie Bower; Chiara Cossetti; Aloka De Sa; Madeline Epping; Stuart Fawke; Nick Gleadall; Richard Grenfell; Andrew Hinch; Oisin Huhn; Sarah Jackson; Isobel Jarvis; Ben Krishna; Daniel Lewis; Joe Marsden; Francesca Nice; Georgina Okecha; Ommar Omarjee; Marianne Perera; Martin Potts; Nathan Richoz; Veronika Romashova; Natalia Savinykh Yarkoni; Rahul Sharma; Luca Stefanucci; Jonathan Stephens; Mateusz Strezlecki; Lori Turner; Eckart M. D. D. De Bie; Katherine Bunclark; Masa Josipovic; Michael Mackay; Alice Michael; Sabrina Rossi; Mayurun Selvan; Sarah Spencer; Cissy Yong; Ali Ansaripour; Alice Michael; Lucy Mwaura; Caroline Patterson; Gary Polwarth; Petra Polgarova; Giovanni di Stefano; Codie Fahey; Rachel Michel; Sze-How Bong; Jerome D. Coudert; Elaine Holmes; John Allison; Helen Butcher; Daniela Caputo; Debbie Clapham-Riley; Eleanor Dewhurst; Anita Furlong; Barbara Graves; Jennifer Gray; Tasmin Ivers; Mary Kasanicki; Emma Le Gresley; Rachel Linger; Sarah Meloy; Francesca Muldoon; Nigel Ovington; Sofia Papadia; Isabel Phelan; Hannah Stark; Kathleen E. Stirrups; Paul Townsend; Neil Walker; Jennifer Webster; Anne Elmer; Nathalie Kingston; Barbara Graves; Emma Le Gresley; Daniela Caputo; Laura Bergamaschi; Kenneth G. C. Smith; John R. Bradley; Lourdes Ceron-Gutierrez; Paulina Cortes-Acevedo; Gabriela Barcenas-Morales; Michelle A. Linterman; Laura E. McCoy; Chris Davis; Emma Thomson; Paul A. Lyons; Eoin McKinney; Rainer Doffinger; Mark Wills; Ravindra K. Gupta; ; ; ; ; ; ; ; ; ; ;
<jats:title>Abstract</jats:title><jats:p>Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age<jats:sup>1</jats:sup>. Here we analysed immune responses following vaccination with the BNT162b2 mRNA vaccine<jats:sup>2</jats:sup> in elderly participants and younger healthcare workers. Serum neutralization and levels of binding IgG or IgA after the first vaccine dose were lower in older individuals, with a marked drop in participants over eighty years old. Sera from participants above eighty showed lower neutralization potency against the B.1.1.7 (Alpha), B.1.351 (Beta) and P.1. (Gamma) VOC than against the wild-type virus and were more likely to lack any neutralization against VOC following the first dose. However, following the second dose, neutralization against VOC was detectable regardless of age. The frequency of SARS-CoV-2 spike-specific memory B cells was higher in elderly responders (whose serum showed neutralization activity) than in non-responders after the first dose. Elderly participants showed a clear reduction in somatic hypermutation of class-switched cells. The production of interferon-γ and interleukin-2 by SARS-CoV-2 spike-specific T cells was lower in older participants, and both cytokines were secreted primarily by CD4 T cells. We conclude that the elderly are a high-risk population and that specific measures to boost vaccine responses in this population are warranted, particularly where variants of concern are circulating.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 417-422
Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques
Jingyou Yu; Lisa H. Tostanoski; Noe B. Mercado; Katherine McMahan; Jinyan Liu; Catherine Jacob-Dolan; Abishek Chandrashekar; Caroline Atyeo; David R. Martinez; Tochi Anioke; Esther A. Bondzie; Aiquan Chang; Sarah Gardner; Victoria M. Giffin; David L. Hope; Felix Nampanya; Joseph Nkolola; Shivani Patel; Owen Sanborn; Daniel Sellers; Huahua Wan; Tammy Hayes; Katherine Bauer; Laurent Pessaint; Daniel Valentin; Zack Flinchbaugh; Renita Brown; Anthony Cook; Deandre Bueno-Wilkerson; Elyse Teow; Hanne Andersen; Mark G. Lewis; Amanda J. Martinot; Ralph S. Baric; Galit Alter; Frank Wegmann; Roland Zahn; Hanneke Schuitemaker; Dan H. Barouch
<jats:title>Abstract</jats:title><jats:p>The emergence of SARS-CoV-2 variants that partially evade neutralizing antibodies poses a threat to the efficacy of current COVID-19 vaccines<jats:sup>1,2</jats:sup>. The Ad26.COV2.S vaccine expresses a stabilized spike protein from the WA1/2020 strain of SARS-CoV-2, and has recently demonstrated protective efficacy against symptomatic COVID-19 in humans in several geographical regions—including in South Africa, where 95% of sequenced viruses in cases of COVID-19 were the B.1.351 variant<jats:sup>3</jats:sup>. Here we show that Ad26.COV2.S elicits humoral and cellular immune responses that cross-react with the B.1.351 variant and protects against B.1.351 challenge in rhesus macaques. Ad26.COV2.S induced lower binding and neutralizing antibodies against B.1.351 as compared to WA1/2020, but elicited comparable CD8 and CD4 T cell responses against the WA1/2020, B.1.351, B.1.1.7, P.1 and CAL.20C variants. B.1.351 infection of control rhesus macaques resulted in higher levels of virus replication in bronchoalveolar lavage and nasal swabs than did WA1/2020 infection. Ad26.COV2.S provided robust protection against both WA1/2020 and B.1.351, although we observed higher levels of virus in vaccinated macaques after B.1.351 challenge. These data demonstrate that Ad26.COV2.S provided robust protection against B.1.351 challenge in rhesus macaques. Our findings have important implications for vaccine control of SARS-CoV-2 variants of concern.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 423-427
In silico saturation mutagenesis of cancer genes
Ferran Muiños; Francisco Martínez-Jiménez; Oriol Pich; Abel Gonzalez-Perez; Nuria Lopez-Bigas
Palabras clave: Multidisciplinary.
Pp. 428-432