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Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

Tabla de contenidos

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doi: 10.1038/s41586-021-03738-2

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

Jackson S. Turner; Jane A. O’Halloran; Elizaveta Kalaidina; Wooseob Kim; Aaron J. Schmitz; Julian Q. Zhou; Tingting Lei; Mahima Thapa; Rita E. Chen; James Brett Case; Fatima Amanat; Adriana M. Rauseo; Alem Haile; Xuping Xie; Michael K. Klebert; Teresa Suessen; William D. Middleton; Pei-Yong Shi; Florian Krammer; Sharlene A. Teefey; Michael S. Diamond; Rachel M. Presti; Ali H. Ellebedy

Palabras clave: Multidisciplinary.

Pp. 109-113

doi: 10.1038/s41586-021-03722-w

Adaptive immunity induces mutualism between commensal eukaryotes

Kyla S. Ost; Teresa R. O’Meara; W. Zac Stephens; Tyson Chiaro; Haoyang Zhou; Jourdan Penman; Rickesha Bell; Jason R. Catanzaro; Deguang Song; Shakti Singh; Daniel H. Call; Elizabeth Hwang-Wong; Kimberly E. Hanson; John F. Valentine; Kenneth A. Christensen; Ryan M. O’Connell; Brendan Cormack; Ashraf S. Ibrahim; Noah W. Palm; Suzanne M. Noble; June L. Round

Palabras clave: Multidisciplinary.

Pp. 114-118

doi: 10.1038/s41586-021-03704-y

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma

Giacomo Oliveira; Kari Stromhaug; Susan Klaeger; Tomasz Kula; Dennie T. Frederick; Phuong M. Le; Juliet Forman; Teddy Huang; Shuqiang Li; Wandi Zhang; Qikai Xu; Nicoletta Cieri; Karl R. Clauser; Sachet A. Shukla; Donna Neuberg; Sune Justesen; Gavin MacBeath; Steven A. Carr; Edward F. Fritsch; Nir Hacohen; Moshe Sade-Feldman; Kenneth J. Livak; Genevieve M. Boland; Patrick A. Ott; Derin B. Keskin; Catherine J. Wu

Palabras clave: Multidisciplinary.

Pp. 119-125

doi: 10.1038/s41586-021-03752-4

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

Justina X. Caushi; Jiajia Zhang; Zhicheng Ji; Ajay Vaghasia; Boyang Zhang; Emily Han-Chung Hsiue; Brian J. Mog; Wenpin Hou; Sune Justesen; Richard Blosser; Ada Tam; Valsamo Anagnostou; Tricia R. Cottrell; Haidan Guo; Hok Yee Chan; Dipika Singh; Sampriti Thapa; Arbor G. Dykema; Poromendro Burman; Begum Choudhury; Luis Aparicio; Laurene S. Cheung; Mara Lanis; Zineb Belcaid; Margueritta El Asmar; Peter B. Illei; Rulin Wang; Jennifer Meyers; Kornel Schuebel; Anuj Gupta; Alyza Skaist; Sarah Wheelan; Jarushka Naidoo; Kristen A. Marrone; Malcolm Brock; Jinny Ha; Errol L. Bush; Bernard J. Park; Matthew Bott; David R. Jones; Joshua E. Reuss; Victor E. Velculescu; Jamie E. Chaft; Kenneth W. Kinzler; Shibin Zhou; Bert Vogelstein; Janis M. Taube; Matthew D. Hellmann; Julie R. Brahmer; Taha Merghoub; Patrick M. Forde; Srinivasan Yegnasubramanian; Hongkai Ji; Drew M. Pardoll; Kellie N. Smith

<jats:title>Abstract</jats:title><jats:p>PD-1 blockade unleashes CD8 T cells<jats:sup>1</jats:sup>, including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell responses. Single-cell transcriptomics have revealed global T cell dysfunction programs in tumour-infiltrating lymphocytes (TIL). However, the majority of TIL do not recognize tumour antigens<jats:sup>2</jats:sup>, and little is known about transcriptional programs of MANA-specific TIL. Here, we identify MANA-specific T cell clones using the MANA functional expansion of specific T cells assay<jats:sup>3</jats:sup> in neoadjuvant anti-PD-1-treated non-small cell lung cancers (NSCLC). We use their T cell receptors as a â€˜barcodeâ€™ to track and analyse their transcriptional programs in the tumour microenvironment using coupled single-cell RNA sequencing and T cell receptor sequencing. We find both MANA- and virus-specific clones in TIL, regardless of response, and MANA-, influenza- and Epsteinâ€“Barr virus-specific TIL each have unique transcriptional programs. Despite exposure to cognate antigen, MANA-specific TIL express an incompletely activated cytolytic program. MANA-specific CD8 T cells have hallmark transcriptional programs of tissue-resident memory (TRM) cells, but low levels of interleukin-7 receptor (IL-7R) and are functionally less responsive to interleukin-7 (IL-7) compared with influenza-specific TRM cells. Compared with those from responding tumours, MANA-specific clones from non-responding tumours express T cell receptors with markedly lower ligand-dependent signalling, are largely confined to HOBIT<jats:sup>high</jats:sup> TRM subsets, and coordinately upregulate checkpoints, killer inhibitory receptors and inhibitors of T cell activation. These findings provide important insights for overcoming resistance to PD-1 blockade.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 126-132