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Nature

Resumen/Descripción – provisto por la editorial en inglés

Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

Palabras clave – provistas por la editorial

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No detectada	desde jul. 2012 / hasta dic. 2023	Nature.com
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Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

1869-

Cobertura temática

Ciencias naturales

Ingeniería y tecnología

Ciencias médicas y de la salud

Ciencias agrícolas y veterinarias

Tabla de contenidos

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doi: 10.1038/s41586-021-03692-z

Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine

Guotong Fu; Clifford S. Guy; Nicole M. Chapman; Gustavo Palacios; Jun Wei; Peipei Zhou; Lingyun Long; Yong-Dong Wang; Chenxi Qian; Yogesh Dhungana; Hongling Huang; Anil KC; Hao Shi; Sherri Rankin; Scott A. Brown; Amanda Johnson; Randall Wakefield; Camenzind G. Robinson; Xueyan Liu; Anthony Sheyn; Jiyang Yu; Suzanne Jackowski; Hongbo Chi

Palabras clave: Multidisciplinary.

Pp. 724-729

doi: 10.1038/s41586-021-03741-7

EGFR activation limits the response of liver cancer to lenvatinib

Haojie Jin; Yaoping Shi; Yuanyuan Lv; Shengxian Yuan; Christel F. A. Ramirez; Cor Lieftink; Liqin Wang; Siying Wang; Cun Wang; Matheus Henrique Dias; Fleur Jochems; Yuan Yang; Astrid Bosma; E. Marielle Hijmans; Marnix H. P. de Groot; Serena Vegna; Dan Cui; Yangyang Zhou; Jing Ling; Hui Wang; Yuchen Guo; Xingling Zheng; Nikita Isima; Haiqiu Wu; Chong Sun; Roderick L. Beijersbergen; Leila Akkari; Weiping Zhou; Bo Zhai; Wenxin Qin; René Bernards

Palabras clave: Multidisciplinary.

Pp. 730-734

doi: 10.1038/s41586-021-03577-1

Enhancer release and retargeting activates disease-susceptibility genes

Soohwan Oh; Jiaofang Shao; Joydeep Mitra; Feng Xiong; Matteo D’Antonio; Ruoyu Wang; Ivan Garcia-Bassets; Qi Ma; Xiaoyu Zhu; Joo-Hyung Lee; Sreejith J. Nair; Feng Yang; Kenneth Ohgi; Kelly A. Frazer; Zhengdong D. Zhang; Wenbo Li; Michael G. Rosenfeld

Palabras clave: Multidisciplinary.

Pp. 735-740

doi: 10.1038/s41586-021-03713-x

Structural basis of early translocation events on the ribosome

Emily J. Rundlet; Mikael Holm; Magdalena Schacherl; S. Kundhavai Natchiar; Roger B. Altman; Christian M. T. Spahn; Alexander G. Myasnikov; Scott C. Blanchard

<jats:title>Abstract</jats:title><jats:p>Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA selection and translocation reactions that proceed rapidly (2â€“20Â per second) and with a low error rate (around 10<jats:sup>âˆ’3</jats:sup>Â toÂ 10<jats:sup>âˆ’5</jats:sup> at each step) over thousands of cycles<jats:sup>1</jats:sup>. The cadence and fidelity of ribosome transit through mRNA templates in discrete codon increments is a paradigm for movement in biological systems that must hold for diverse mRNA and tRNA substrates across domains of life. Here we use single-molecule fluorescence methods to guide the capture of structures of early translocation events on the bacterial ribosome. Our findings reveal that the bacterial GTPase elongation factor G specifically engages spontaneously achieved ribosome conformations while in an active, GTP-bound conformation to unlock and initiate peptidyl-tRNA translocation. These findings suggest that processes intrinsic to the pre-translocation ribosome complex can regulate the rate of protein synthesis, and that energy expenditure is used later in the translocation mechanism than previously proposed.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 741-745