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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Optical manipulation of electronic dimensionality in a quantum material
Shaofeng Duan; Yun Cheng; Wei Xia; Yuanyuan Yang; Chengyang Xu; Fengfeng Qi; Chaozhi Huang; Tianwei Tang; Yanfeng Guo
; Weidong Luo; Dong Qian; Dao Xiang; Jie Zhang; Wentao Zhang
Palabras clave: Multidisciplinary.
Pp. 239-244
Bifunctional nanoprecipitates strengthen and ductilize a medium-entropy alloy
Ying Yang; Tianyi Chen; Lizhen Tan; Jonathan D. Poplawsky; Ke An; Yanli Wang; German D. Samolyuk; Ken Littrell; Andrew R. Lupini; Albina Borisevich; Easo P. George
Palabras clave: Multidisciplinary.
Pp. 245-249
Supply chain diversity buffers cities against food shocks
Michael Gomez; Alfonso Mejia; Benjamin L. Ruddell; Richard R. Rushforth
Palabras clave: Multidisciplinary.
Pp. 250-254
Fluid-rich subducting topography generates anomalous forearc porosity
Christine Chesley; Samer Naif; Kerry Key; Dan Bassett
Palabras clave: Multidisciplinary.
Pp. 255-260
GluD1 is a signal transduction device disguised as an ionotropic receptor
Jinye Dai; Christopher Patzke; Kif Liakath-Ali; Erica Seigneur; Thomas C. Südhof
Palabras clave: Multidisciplinary.
Pp. 261-265
Obesity accelerates hair thinning by stem cell-centric converging mechanisms
Hironobu Morinaga; Yasuaki Mohri; Marina Grachtchouk; Kyosuke Asakawa; Hiroyuki Matsumura; Motohiko Oshima; Naoya Takayama; Tomoki Kato; Yuriko Nishimori; Yuriko Sorimachi; Keiyo Takubo; Takayoshi Suganami; Atsushi Iwama; Yoichiro Iwakura; Andrzej A. Dlugosz; Emi K. Nishimura
Palabras clave: Multidisciplinary.
Pp. 266-271
Caloric restriction disrupts the microbiota and colonization resistance
Reiner Jumpertz von Schwartzenberg; Jordan E. Bisanz; Svetlana Lyalina; Peter Spanogiannopoulos; Qi Yan Ang; Jingwei Cai; Sophia Dickmann; Marie Friedrich; Su-Yang Liu; Stephanie L. Collins; Danielle Ingebrigtsen; Steve Miller; Jessie A. Turnbaugh; Andrew D. Patterson; Katherine S. Pollard; Knut Mai; Joachim Spranger; Peter J. Turnbaugh
Palabras clave: Multidisciplinary.
Pp. 272-277
Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants
Jianliang Xu; Kai Xu; Seolkyoung Jung; Andrea Conte; Jenna Lieberman; Frauke Muecksch; Julio Cesar Cetrulo Lorenzi; Solji Park; Fabian Schmidt; Zijun Wang; Yaoxing Huang; Yang Luo; Manoj S. Nair; Pengfei Wang; Jonathan E. Schulz; Lino Tessarollo; Tatsiana Bylund; Gwo-Yu Chuang; Adam S. Olia; Tyler Stephens; I-Ting Teng; Yaroslav Tsybovsky; Tongqing Zhou; Vincent Munster; David D. Ho; Theodora Hatziioannou; Paul D. Bieniasz; Michel C. Nussenzweig; Peter D. Kwong; Rafael Casellas
<jats:title>Abstract</jats:title><jats:p>Since the start of the COVID-19 pandemic, SARS-CoV-2 has caused millions of deaths worldwide. Although a number of vaccines have been deployed, the continual evolution of the receptor-binding domain (RBD) of the virus has challenged their efficacy. In particular, the emerging variants B.1.1.7, B.1.351 and P.1 (first detected in the UK, South Africa and Brazil, respectively) have compromised the efficacy of sera from patients who have recovered from COVID-19 and immunotherapies that have received emergency use authorization<jats:sup>1–3</jats:sup>. One potential alternative to avert viral escape is the use of camelid VHHs (variable heavy chain domains of heavy chain antibody (also known as nanobodies)), which can recognize epitopes that are often inaccessible to conventional antibodies<jats:sup>4</jats:sup>. Here, we isolate anti-RBD nanobodies from llamas and from mice that we engineered to produce VHHs cloned from alpacas, dromedaries and Bactrian camels. We identified two groups of highly neutralizing nanobodies. Group 1 circumvents antigenic drift by recognizing an RBD region that is highly conserved in coronaviruses but rarely targeted by human antibodies. Group 2 is almost exclusively focused to the RBD–ACE2 interface and does not neutralize SARS-CoV-2 variants that carry E484K or N501Y substitutions. However, nanobodies in group 2 retain full neutralization activity against these variants when expressed as homotrimers, and—to our knowledge—rival the most potent antibodies against SARS-CoV-2 that have been produced to date. These findings suggest that multivalent nanobodies overcome SARS-CoV-2 mutations through two separate mechanisms: enhanced avidity for the ACE2-binding domain and recognition of conserved epitopes that are largely inaccessible to human antibodies. Therefore, although new SARS-CoV-2 mutants will continue to emerge, nanobodies represent promising tools to prevent COVID-19 mortality when vaccines are compromised.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 278-282
Diverse functional autoantibodies in patients with COVID-19
Eric Y. Wang; Tianyang Mao; Jon Klein; Yile Dai; John D. Huck; Jillian R. Jaycox; Feimei Liu; Ting Zhou; Benjamin Israelow; Patrick Wong; Andreas Coppi; Carolina Lucas; Julio Silva; Ji Eun Oh; Eric Song; Emily S. Perotti; Neil S. Zheng; Suzanne Fischer; Melissa Campbell; John B. Fournier; Anne L. Wyllie; Chantal B. F. Vogels; Isabel M. Ott; Chaney C. Kalinich; Mary E. Petrone; Anne E. Watkins; Abeer Obaid; Adam J. Moore; Arnau Casanovas-Massana; Alice Lu-Culligan; Allison Nelson; Angela Nunez; Anjelica Martin; Bertie Geng; Camila D. Odio; Christina A. Harden; Codruta Todeasa; Cole Jensen; Daniel Kim; David McDonald; Denise Shepard; Edward Courchaine; Elizabeth B. White; Erin Silva; Eriko Kudo; Giuseppe DeIuliis; Harold Rahming; Hong-Jai Park; Irene Matos; Jessica Nouws; Jordan Valdez; Joseph Lim; Kadi-Ann Rose; Kelly Anastasio; Kristina Brower; Laura Glick; Lokesh Sharma; Lorenzo Sewanan; Lynda Knaggs; Maksym Minasyan; Maria Batsu; Maxine Kuang; Maura Nakahata; Melissa Linehan; Michael H. Askenase; Michael Simonov; Mikhail Smolgovsky; Nicole Sonnert; Nida Naushad; Pavithra Vijayakumar; Rick Martinello; Rupak Datta; Ryan Handoko; Santos Bermejo; Sarah Prophet; Sean Bickerton; Sofia Velazquez; Tyler Rice; William Khoury-Hanold; Xiaohua Peng; Yexin Yang; Yiyun Cao; Yvette Strong; Charles Dela Cruz; Shelli F. Farhadian; Wade L. Schulz; Shuangge Ma; Nathan D. Grubaugh; Albert I. Ko; Akiko Iwasaki; Aaron M. Ring;
Palabras clave: Multidisciplinary.
Pp. 283-288
Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity
Agnes Mwakingwe-Omari; Sara A. Healy; Jacquelyn Lane; David M. Cook; Sahand Kalhori; Charles Wyatt; Aarti Kolluri; Omely Marte-Salcedo; Alemush Imeru; Martha Nason; Lei K. Ding; Hope Decederfelt; Junhui Duan; Jillian Neal; Jacob Raiten; Grace Lee; Jen C. C. Hume; Jihyun E. Jeon; Ijeoma Ikpeama; Natasha KC; Sumana Chakravarty; Tooba Murshedkar; L. W. Preston Church; Anita Manoj; Anusha Gunasekera; Charles Anderson; Sean C. Murphy; Sandra March; Sangeeta N. Bhatia; Eric R. James; Peter F. Billingsley; B. Kim Lee Sim; Thomas L. Richie; Irfan Zaidi; Stephen L. Hoffman; Patrick E. Duffy
Palabras clave: Multidisciplinary.
Pp. 289-294