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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Astronomers are worried by a satellite brighter than most stars
Benjamin Thompson; Nick Petrić Howe
Palabras clave: Multidisciplinary.
Pp. No disponible
Climate change and habitat loss push amphibians closer to extinction
Palabras clave: Multidisciplinary.
Pp. No disponible
Author Correction: Synthesis of portimines reveals the basis of their anti-cancer activity
Junchen Tang
; Weichao Li; Tzu-Yuan Chiu; Francisco Martínez-Peña; Zengwei Luo; Christine T. Chong; Qijia Wei; Nathalia Gazaniga; Thomas J. West; Yi Yang See; Luke L. Lairson; Christopher G. Parker; Phil S. Baran
Palabras clave: Multidisciplinary.
Pp. No disponible
‘In case I die, I need to publish this paper’: scientist who left the lab to fight in Ukraine
Layal Liverpool
Palabras clave: Multidisciplinary.
Pp. No disponible
South Korean scientists’ outcry over planned R&D budget cuts
Sara Reardon
Palabras clave: Multidisciplinary.
Pp. No disponible
How carrots became orange: genomics get at the root of the matter
Palabras clave: Multidisciplinary.
Pp. No disponible
Global evidence of rapid urban growth in flood zones since 1985
Jun Rentschler; Paolo Avner; Mattia Marconcini; Rui Su; Emanuele Strano; Michalis Vousdoukas; Stéphane Hallegatte
Palabras clave: Multidisciplinary.
Pp. 87-92
Gene therapies for rare diseases are under threat. Scientists hope to save them
Heidi Ledford
Palabras clave: Multidisciplinary.
Pp. No disponible
How ChatGPT and other AI tools could disrupt scientific publishing
Gemma Conroy
Palabras clave: Multidisciplinary.
Pp. 234-236
Bacteriophages suppress CRISPR–Cas immunity using RNA-based anti-CRISPRs
Sarah Camara-Wilpert; David Mayo-Muñoz; Jakob Russel; Robert D. Fagerlund; Jonas S. Madsen; Peter C. Fineran; Søren J. Sørensen; Rafael Pinilla-Redondo
<jats:title>Abstract</jats:title><jats:p>Many bacteria use CRISPR–Cas systems to combat mobile genetic elements, such as bacteriophages and plasmids<jats:sup>1</jats:sup>. In turn, these invasive elements have evolved anti-CRISPR proteins to block host immunity<jats:sup>2,3</jats:sup>. Here we unveil a distinct type of CRISPR–Cas Inhibition strategy that is based on small non-coding <jats:underline>R</jats:underline>NA <jats:underline>a</jats:underline>nti-<jats:underline>CR</jats:underline>ISPRs (Racrs). Racrs mimic the repeats found in CRISPR arrays and are encoded in viral genomes as solitary repeat units<jats:sup>4</jats:sup>. We show that a prophage-encoded Racr strongly inhibits the type I-F CRISPR–Cas system by interacting specifically with Cas6f and Cas7f, resulting in the formation of an aberrant Cas subcomplex. We identified Racr candidates for almost all CRISPR–Cas types encoded by a diverse range of viruses and plasmids, often in the genetic context of other anti-CRISPR genes<jats:sup>5</jats:sup>. Functional testing of nine candidates spanning the two CRISPR–Cas classes confirmed their strong immune inhibitory function. Our results demonstrate that molecular mimicry of CRISPR repeats is a widespread anti-CRISPR strategy, which opens the door to potential biotechnological applications<jats:sup>6</jats:sup>.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible