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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Concern at Cochrane: evidence giant battles funding cuts and closures
Helen Pearson
Palabras clave: Multidisciplinary.
Pp. No disponible
How would room-temperature superconductors change science?
Davide Castelvecchi
Palabras clave: Multidisciplinary.
Pp. No disponible
Author Correction: Women are credited less in science than men
Matthew B. Ross; Britta M. Glennon
; Raviv Murciano-Goroff; Enrico G. Berkes; Bruce A. Weinberg; Julia I. Lane
Palabras clave: Multidisciplinary.
Pp. No disponible
Surprising reaction pathway observed in lithium–sulfur batteries
Palabras clave: Multidisciplinary.
Pp. No disponible
An ‘alien meteorite’ probably didn’t slam into Earth — how will we know if one does?
Alexandra Witze
Palabras clave: Multidisciplinary.
Pp. No disponible
How to supercharge T cells against cancer
Nick Petrić Howe
Palabras clave: Multidisciplinary.
Pp. No disponible
Specialized astrocytes mediate glutamatergic gliotransmission in the CNS
Roberta de Ceglia; Ada Ledonne; David Gregory Litvin; Barbara Lykke Lind; Giovanni Carriero; Emanuele Claudio Latagliata; Erika Bindocci; Maria Amalia Di Castro; Iaroslav Savtchouk; Ilaria Vitali; Anurag Ranjak; Mauro Congiu; Tara Canonica; William Wisden; Kenneth Harris; Manuel Mameli; Nicola Mercuri; Ludovic Telley; Andrea Volterra
<jats:title>Abstract</jats:title><jats:p>Multimodal astrocyte–neuron communications govern brain circuitry assembly and function<jats:sup>1</jats:sup>. For example, through rapid glutamate release, astrocytes can control excitability, plasticity and synchronous activity<jats:sup>2,3</jats:sup> of synaptic networks, while also contributing to their dysregulation in neuropsychiatric conditions<jats:sup>4–7</jats:sup>. For astrocytes to communicate through fast focal glutamate release, they should possess an apparatus for Ca<jats:sup>2+</jats:sup>-dependent exocytosis similar to neurons<jats:sup>8–10</jats:sup>. However, the existence of this mechanism has been questioned<jats:sup>11–13</jats:sup> owing to inconsistent data<jats:sup>14–17</jats:sup> and a lack of direct supporting evidence. Here we revisited the astrocyte glutamate exocytosis hypothesis by considering the emerging molecular heterogeneity of astrocytes<jats:sup>18–21</jats:sup> and using molecular, bioinformatic and imaging approaches, together with cell-specific genetic tools that interfere with glutamate exocytosis in vivo. By analysing existing single-cell RNA-sequencing databases and our patch-seq data, we identified nine molecularly distinct clusters of hippocampal astrocytes, among which we found a notable subpopulation that selectively expressed synaptic-like glutamate-release machinery and localized to discrete hippocampal sites. Using GluSnFR-based glutamate imaging<jats:sup>22</jats:sup> in situ and in vivo, we identified a corresponding astrocyte subgroup that responds reliably to astrocyte-selective stimulations with subsecond glutamate release events at spatially precise hotspots, which were suppressed by astrocyte-targeted deletion of vesicular glutamate transporter 1 (VGLUT1). Furthermore, deletion of this transporter or its isoform VGLUT2 revealed specific contributions of glutamatergic astrocytes in cortico-hippocampal and nigrostriatal circuits during normal behaviour and pathological processes. By uncovering this atypical subpopulation of specialized astrocytes in the adult brain, we provide insights into the complex roles of astrocytes in central nervous system (CNS) physiology and diseases, and identify a potential therapeutic target.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Hydrogen-bond-acceptor ligands enable distal C(sp3)–H arylation of free alcohols
Daniel A. Strassfeld; Chia-Yu Chen; Han Seul Park; D. Quang Phan; Jin-Quan Yu
Palabras clave: Multidisciplinary.
Pp. No disponible
Dynamic regulation of messenger RNA structure controls translation
Yizhu Lin; Stephen N. Floor
Palabras clave: Multidisciplinary.
Pp. No disponible
Thymic mimetic cells function beyond self-tolerance
Tal Givony; Dena Leshkowitz; Diana Del Castillo; Shir Nevo; Noam Kadouri; Bareket Dassa; Yael Gruper; Razi Khalaila; Osher Ben-Nun; Tom Gome; Jan Dobeš; Shifra Ben-Dor; Merav Kedmi; Hadas Keren-Shaul; Rebecca Heffner-Krausz; Ziv Porat; Ofra Golani; Yoseph Addadi; Ori Brenner; David D. Lo; Yael Goldfarb; Jakub Abramson
Palabras clave: Multidisciplinary.
Pp. No disponible