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Nature

Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.
Palabras clave – provistas por la editorial

No disponibles.

Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde jul. 2012 / hasta dic. 2023 Nature.com
No detectada desde jul. 2006 / hasta ago. 2012 Ovid

Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Cobertura temática

naturales

Ciencias naturales

ingenieria

Ingeniería y tecnología

medicina

Ciencias médicas y de la salud

agrarias

Ciencias agrícolas y veterinarias

Tabla de contenidos

doi: 10.1038/d41586-022-02250-5

‘Illusion shell’ makes objects sound like something they’re not

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/d41586-022-02305-7

Defence research, charm quark — the week in infographics

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/d41586-022-02282-x

Designer antiviral takes aim at one of influenza’s soft spots

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/d41586-022-02315-5

Daily briefing: Spectacular Jupiter image from James Webb Space Telescope

Emma Stoye

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/s41586-022-05211-0

Photoexcited Nitroarenes for the Oxidative Cleavage of Alkenes

Alessandro RuffoniORCID; Charlotte Hampton; Marco Simonetti; Daniele LeonoriORCID

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/d41586-022-02246-1

Ancient tooth DNA reveals how ‘cold sore’ herpes virus has evolved

Freda Kreier

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/d41586-022-02248-z

A restful way to feel more generous: get more sleep

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/d41586-022-02327-1

Daily briefing: Do tiny blood clots cause long COVID?

Flora Graham

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/s41586-022-05121-1

Mechanism of AAA+ ATPase-mediated RuvAB–Holliday junction branch migration

Jiri WaldORCID; Dirk FahrenkampORCID; Nikolaus Goessweiner-Mohr; Wolfgang LugmayrORCID; Luciano Ciccarelli; Oliver Vesper; Thomas C. MarlovitsORCID

<jats:title>Abstract</jats:title><jats:p>The Holliday junction is a key intermediate formed during DNA recombination across all kingdoms of life<jats:sup>1</jats:sup>. In bacteria, the Holliday junction is processed by two homo-hexameric AAA+ ATPase RuvB motors, which assemble together with the RuvA–Holliday junction complex to energize the strand-exchange reaction<jats:sup>2</jats:sup>. Despite its importance for chromosome maintenance, the structure and mechanism by which this complex facilitates branch migration are unknown. Here, using time-resolved cryo-electron microscopy, we obtained structures of the ATP-hydrolysing RuvAB complex in seven distinct conformational states, captured during assembly and processing of a Holliday junction. Five structures together resolve the complete nucleotide cycle and reveal the spatiotemporal relationship between ATP hydrolysis, nucleotide exchange and context-specific conformational changes in RuvB. Coordinated motions in a converter formed by DNA-disengaged RuvB subunits stimulate hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, which generates the pulling force driving the branch migration. We show that RuvB motors rotate together with the DNA substrate, which, together with a progressing nucleotide cycle, forms the mechanistic basis for DNA recombination by continuous branch migration. Together, our data decipher the molecular principles of homologous recombination by the RuvAB complex, elucidate discrete and sequential transition-state intermediates for chemo-mechanical coupling of hexameric AAA+ motors and provide a blueprint for the design of state-specific compounds targeting AAA+ motors.</jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible

doi: 10.1038/d41586-022-02293-8

NASA’s Artemis Moon mission is set to launch: here’s the science on board

Alexandra Witze

Palabras clave: Multidisciplinary.

Pp. No disponible