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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Structural keys unlock RAS–MAPK cellular signalling pathway
Hugo Lavoie; Marc Therrien
Palabras clave: Multidisciplinary.
Pp. No disponible
A massive planet circles a huge star doomed to explode
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: The impact of overturning Roe v. Wade in seven charts
Anne Marie Conlon
Palabras clave: Multidisciplinary.
Pp. No disponible
From the archive: comparing crystals and cells, and the Copernicus satellite’s launch
Palabras clave: Multidisciplinary.
Pp. No disponible
Should parents delay kids’ second COVID vaccine? Here’s what the research says
Shannon Hall
Palabras clave: Multidisciplinary.
Pp. No disponible
Healthy foods, COVID rebound — the week in infographics
Palabras clave: Multidisciplinary.
Pp. No disponible
Notorious dark-matter signal could be due to analysis error
Davide Castelvecchi
Palabras clave: Multidisciplinary.
Pp. No disponible
Scientists welcome ‘enormous’ US climate bill — but call for stronger action
Gayathri Vaidyanathan
Palabras clave: Multidisciplinary.
Pp. No disponible
How much virus does a person with COVID exhale? New research has answers
McKenzie Prillaman
Palabras clave: Multidisciplinary.
Pp. No disponible
MYB orchestrates T cell exhaustion and response to checkpoint inhibition
Carlson Tsui
; Lorenz Kretschmer; Svenja Rapelius; Sarah S. Gabriel; David Chisanga; Konrad Knöpper; Daniel T. Utzschneider; Simone Nüssing; Yang Liao; Teisha Mason; Santiago Valle Torres; Stephen A. Wilcox; Krystian Kanev; Sebastian Jarosch; Justin Leube; Stephen L. Nutt; Dietmar Zehn; Ian A. Parish; Wolfgang Kastenmüller; Wei Shi; Veit R. Buchholz; Axel Kallies
<jats:title>Abstract</jats:title><jats:p>CD8<jats:sup>+</jats:sup> T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by the impaired production of cytokines. This state of restrained functionality—which is referred to as T cell exhaustion<jats:sup>1,2</jats:sup>—is maintained by precursors of exhausted T (T<jats:sub>PEX</jats:sub>) cells that express the transcription factor T cell factor 1 (TCF1), self-renew and give rise to TCF1<jats:sup>−</jats:sup> exhausted effector T cells<jats:sup>3–6</jats:sup>. Here we show that the long-term proliferative potential, multipotency and repopulation capacity of exhausted T cells during chronic infection are selectively preserved in a small population of transcriptionally distinct CD62L<jats:sup>+</jats:sup> T<jats:sub>PEX</jats:sub> cells. The transcription factor MYB is not only essential for the development of CD62L<jats:sup>+</jats:sup> T<jats:sub>PEX</jats:sub> cells and maintenance of the antiviral CD8<jats:sup>+</jats:sup> T cell response, but also induces functional exhaustion and thereby prevents lethal immunopathology. Furthermore, the proliferative burst in response to PD-1 checkpoint inhibition originates exclusively from CD62L<jats:sup>+</jats:sup> T<jats:sub>PEX</jats:sub> cells and depends on MYB. Our findings identify CD62L<jats:sup>+</jats:sup> T<jats:sub>PEX</jats:sub> cells as a stem-like population that is central to the maintenance of long-term antiviral immunity and responsiveness to immunotherapy. Moreover, they show that MYB is a transcriptional orchestrator of two fundamental aspects of exhausted T cell responses: the downregulation of effector function and the long-term preservation of self-renewal capacity.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible