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Nature

Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.
Palabras clave – provistas por la editorial

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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde jul. 2012 / hasta dic. 2023 Nature.com
No detectada desde jul. 2006 / hasta ago. 2012 Ovid

Información

Tipo de recurso:

revistas

ISSN impreso

0028-0836

ISSN electrónico

1476-4687

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Tabla de contenidos

Deciphering the immunopeptidome in vivo reveals new tumour antigens

Alex M. Jaeger; Lauren E. StopferORCID; Ryuhjin AhnORCID; Emma A. Sanders; Demi A. SandelORCID; William A. Freed-PastorORCID; William M. Rideout; Santiago Naranjo; Tim Fessenden; Kim B. Nguyen; Peter S. Winter; Ryan E. Kohn; Peter M. K. WestcottORCID; Jason M. Schenkel; Sean-Luc Shanahan; Alex K. ShalekORCID; Stefani SprangerORCID; Forest M. WhiteORCID; Tyler JacksORCID

Palabras clave: Multidisciplinary.

Pp. 149-155

The metastatic spread of breast cancer accelerates during sleep

Zoi Diamantopoulou; Francesc Castro-GinerORCID; Fabienne Dominique Schwab; Christiane Foerster; Massimo Saini; Selina Budinjas; Karin Strittmatter; Ilona Krol; Bettina Seifert; Viola Heinzelmann-Schwarz; Christian Kurzeder; Christoph Rochlitz; Marcus Vetter; Walter Paul Weber; Nicola AcetoORCID

Palabras clave: Multidisciplinary.

Pp. 156-162

GREM1 is required to maintain cellular heterogeneity in pancreatic cancer

Linxiang LanORCID; Theodore Evan; Huafu Li; Aasia Hussain; E. Josue Ruiz; May Zaw ThinORCID; Rute M. M. Ferreira; Hari Ps; Eva M. Riising; Yoh Zen; Jorge AlmagroORCID; Kevin W. Ng; Pablo Soro-BarrioORCID; Jessica Nelson; Gabriela Koifman; Joana Carvalho; Emma L. Nye; Yulong He; Changhua Zhang; Anguraj SadanandamORCID; Axel BehrensORCID

Palabras clave: Multidisciplinary.

Pp. 163-168

OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage

Xiaoli S. Wu; Xue-Yan HeORCID; Jonathan J. IpsaroORCID; Yu-Han Huang; Jonathan B. Preall; David Ng; Yan Ting Shue; Julien SageORCID; Mikala EgebladORCID; Leemor Joshua-TorORCID; Christopher R. VakocORCID

Palabras clave: Multidisciplinary.

Pp. 169-175

Compatibility rules of human enhancer and promoter sequences

Drew T. BergmanORCID; Thouis R. Jones; Vincent LiuORCID; Judhajeet RayORCID; Evelyn Jagoda; Layla Siraj; Helen Y. Kang; Joseph Nasser; Michael Kane; Antonio RiosORCID; Tung H. Nguyen; Sharon R. Grossman; Charles P. Fulco; Eric S. LanderORCID; Jesse M. EngreitzORCID

Palabras clave: Multidisciplinary.

Pp. 176-184

eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining

Christopher P. LapointeORCID; Rosslyn Grosely; Masaaki Sokabe; Carlos Alvarado; Jinfan WangORCID; Elizabeth Montabana; Nancy Villa; Byung-Sik Shin; Thomas E. DeverORCID; Christopher S. Fraser; Israel S. FernándezORCID; Joseph D. PuglisiORCID

Palabras clave: Multidisciplinary.

Pp. 185-190

Cryo-EM structure of a type IV secretion system

Kévin MacéORCID; Abhinav K. Vadakkepat; Adam RedzejORCID; Natalya LukoyanovaORCID; Clasien Oomen; Nathalie Braun; Marta Ukleja; Fang Lu; Tiago R. D. CostaORCID; Elena V. OrlovaORCID; David BakerORCID; Qian CongORCID; Gabriel WaksmanORCID

<jats:title>Abstract</jats:title><jats:p>Bacterial conjugation is the fundamental process of unidirectional transfer of DNAs, often plasmid DNAs, from a donor cell to a recipient cell<jats:sup>1</jats:sup>. It is the primary means by which antibiotic resistance genes spread among bacterial populations<jats:sup>2,3</jats:sup>. In Gram-negative bacteria, conjugation is mediated by a large transport apparatus—the conjugative type IV secretion system (T4SS)—produced by the donor cell and embedded in both its outer and inner membranes. The T4SS also elaborates a long extracellular filament—the conjugative pilus—that is essential for DNA transfer<jats:sup>4,5</jats:sup>. Here we present a high-resolution cryo-electron microscopy (cryo-EM) structure of a 2.8 megadalton T4SS complex composed of 92 polypeptides representing 8 of the 10 essential T4SS components involved in pilus biogenesis. We added the two remaining components to the structural model using co-evolution analysis of protein interfaces, to enable the reconstitution of the entire system including the pilus. This structure describes the exceptionally large protein–protein interaction network required to assemble the many components that constitute a T4SS and provides insights on the unique mechanism by which they elaborate pili.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 191-196

The conference challenges faced by scientists who stutter

Emily Sohn

Palabras clave: Multidisciplinary.

Pp. 197-199

Need web data? Here’s how to harvest them

Michael Eisenstein

Palabras clave: Multidisciplinary.

Pp. 200-201

Improving livestock to fight poverty and empower women

Nic Fleming

Palabras clave: Multidisciplinary.

Pp. 204-204