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Nature
Resumen/Descripción – provisto por la editorial en inglés
Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde jul. 2012 / hasta dic. 2023 | Nature.com | ||
| No detectada | desde jul. 2006 / hasta ago. 2012 | Ovid |
Información
Tipo de recurso:
revistas
ISSN impreso
0028-0836
ISSN electrónico
1476-4687
Editor responsable
Springer Nature
País de edición
Reino Unido
Fecha de publicación
1869-
Tabla de contenidos
Ed Yong on the wondrous world of animal senses
Benjamin Thompson
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: Ten years since the Higgs boson discovery
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
‘Tree of lice’ pinpoints first mammal with a louse infestation
Colin Barras
Palabras clave: Multidisciplinary.
Pp. No disponible
Daily briefing: Ukrainian mathematician wins Fields Medal
Flora Graham
Palabras clave: Multidisciplinary.
Pp. No disponible
Revealed: the pay bump for being a straight, white man in US science
Clare Watson
Palabras clave: Multidisciplinary.
Pp. No disponible
Vomiting viruses, fruit and veg emissions — the week in infographics
Palabras clave: Multidisciplinary.
Pp. No disponible
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Birte Niemann
; Saskia Haufs-Brusberg; Laura Puetz; Martin Feickert; Michelle Y. Jaeckstein; Anne Hoffmann; Jelena Zurkovic; Markus Heine; Eva-Maria Trautmann; Christa E. Müller; Anke Tönjes; Christian Schlein; Azin Jafari; Holger K. Eltzschig; Thorsten Gnad; Matthias Blüher; Natalie Krahmer; Peter Kovacs; Joerg Heeren; Alexander Pfeifer
<jats:title>Abstract</jats:title><jats:p>Brown adipose tissue (BAT) dissipates energy<jats:sup>1,2</jats:sup> and promotes cardiometabolic health<jats:sup>3</jats:sup>. Loss of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but not much is known about BAT apoptosis. Here, untargeted metabolomics demonstrated that apoptotic brown adipocytes release a specific pattern of metabolites with purine metabolites being highly enriched. This apoptotic secretome enhances expression of the thermogenic programme in healthy adipocytes. This effect is mediated by the purine inosine that stimulates energy expenditure in brown adipocytes by the cyclic adenosine monophosphate–protein kinase A signalling pathway. Treatment of mice with inosine increased BAT-dependent energy expenditure and induced ‘browning’ of white adipose tissue. Mechanistically, the equilibrative nucleoside transporter 1 (ENT1, SLC29A1) regulates inosine levels in BAT: ENT1-deficiency increases extracellular inosine levels and consequently enhances thermogenic adipocyte differentiation. In mice, pharmacological inhibition of ENT1 as well as global and adipose-specific ablation enhanced BAT activity and counteracted diet-induced obesity, respectively. In human brown adipocytes, knockdown or blockade of ENT1 increased extracellular inosine, which enhanced thermogenic capacity. Conversely, high <jats:italic>ENT1</jats:italic> levels correlated with lower expression of the thermogenic marker <jats:italic>UCP1</jats:italic> in human adipose tissues. Finally, the Ile216Thr loss of function mutation in human <jats:italic>ENT1</jats:italic> was associated with significantly lower body mass index and 59% lower odds of obesity for individuals carrying the Thr variant. Our data identify inosine as a metabolite released during apoptosis with a ‘replace me’ signalling function that regulates thermogenic fat and counteracts obesity.</jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Vortices produced and studied in electron fluids
Palabras clave: Multidisciplinary.
Pp. No disponible
Higgs boson turns ten: the mysteries physicists are still trying to solve
Benjamin Thompson; Nick Petrić Howe
Palabras clave: Multidisciplinary.
Pp. No disponible
Revealing the origin of the first supermassive black holes
Palabras clave: Multidisciplinary.
Pp. No disponible