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Muscle and Nerve

Resumen/Descripción – provisto por la editorial

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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde ene. 1978 / hasta dic. 2023 Wiley Online Library

Información

Tipo de recurso:

revistas

ISSN impreso

0148-639X

ISSN electrónico

1097-4598

País de edición

Estados Unidos

Cobertura temática

Tabla de contenidos

Quality of life in amyotrophic lateral sclerosis patients and caregivers: Impact of assistive communication from early stages

Ana Londral; Anabela Pinto; Susana Pinto; Luis Azevedo; Mamede De Carvalho

Palabras clave: Physiology (medical); Cellular and Molecular Neuroscience; Neurology (clinical); Physiology.

Pp. 933-941

Revised upper limb module for spinal muscular atrophy: Development of a new module

Elena S. Mazzone; Anna Mayhew; Jacqueline Montes; Danielle Ramsey; Lavinia Fanelli; Sally Dunaway Young; Rachel Salazar; Roberto De Sanctis; Amy Pasternak; Allan Glanzman; Giorgia Coratti; Matthew Civitello; Nicola Forcina; Richard Gee; Tina Duong; Marika Pane; Mariacristina Scoto; Maria Carmela Pera; Sonia Messina; Gihan Tennekoon; John W. Day; Basil T. Darras; Darryl C. Vivo; Richard Finkel; Francesco Muntoni; Eugenio Mercuri

Palabras clave: Physiology (medical); Cellular and Molecular Neuroscience; Neurology (clinical); Physiology.

Pp. 869-874

Provisional best practices guidelines for the evaluation of bulbar dysfunction in amyotrophic lateral sclerosis

Gary L. Pattee; Emily K. PlowmanORCID; Kendrea L. (Focht) Garand; John Costello; Benjamin Rix Brooks; James D. Berry; Richard A. Smith; Nazem Atassi; Jennifer L. Chapin; Yana Yunusova; Courtney E. McIlduff; Eufrosina Young; Eric A. Macklin; Eduardo R. Locatelli; Vincenzo Silani; Daragh Heitzman; James Wymer; Stephen A. GoutmanORCID; Deborah F. Gelinas; Bridget Perry; Paige Nalipinski; Kaila Stipancic; Meghan O'Brien; Stacey L. Sullivan; Erik P. Pioro; Gisella Gargiulo; Jordan R. Green;

Palabras clave: Physiology (medical); Cellular and Molecular Neuroscience; Neurology (clinical); Physiology.

Pp. 531-536

Safety and outcomes of eculizumab for acetylcholine receptor‐positive generalized myasthenia gravis in clinical practice

Joome SuhORCID; Virginia Clarke; Anthony A. Amato; Amanda C. GuidonORCID

<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction/Aims</jats:title><jats:p>Safety and outcomes data on eculizumab for generalized myasthenia gravis (gMG) in clinical practice remain limited. Outcomes and concomitant medication use may differ in practice compared with clinical trials. We analyzed the clinical and safety outcomes of patients who received eculizumab at our institutions.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients with acetylcholine receptor antibody positive (AChR+) gMG, who received ≥1 dose of eculizumab and had ≥1 follow‐up before December 10, 2021, were identified. Data were abstracted by chart review. Outcomes included MG Foundation of America Post Intervention Status (MGFA‐PIS), Clinical Classification (MGFA‐CC), MG‐Activities of Daily Living (MG‐ADL), concurrent immunomodulatory therapy use, and adverse events.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Twelve patients were included. Mean age at eculizumab initiation was 57.4 y (range, 21–77). Eight had refractory MG. Four had history of thymoma and thymectomy. A mean of 3.2 (range, 2–5) immunomodulatory therapies were previously tried. Mean follow‐up duration was 18 mo (range, 2–21.6). Clinical improvement occurred rapidly; MGFA‐PIS was improved in 80%, and MGFA‐CC improved in 83% at 1 mo. Mean MG‐ADL decreased from 8.7 to 2.8 at 1 mo, and remained .5 over 1.5 y. Mean daily prednisone dose decreased from 22.5 mg to 7.2 mg at 1.5 y. Five of 7 patients discontinued maintenance IVIG or PLEX. No patients had meningococcal infections and adverse events were mild.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Clinical improvement occurred in most patients after eculizumab initiation, beginning as quickly as 1 mo. Steroids were tapered and maintenance IVIG and PLEX were discontinued in most. Eculizumab had a favorable safety profile even when combined with other immunosuppressants.</jats:p></jats:sec>

Pp. 348-353

Using machine learning algorithms to enhance the diagnostic performance of electrical impedance myography

Sarbesh R. Pandeya; Janice A. Nagy; Daniela Riveros; Carson Semple; Rebecca S. Taylor; Alice Hu; Benjamin SanchezORCID; Seward B. RutkoveORCID

Palabras clave: Physiology (medical); Cellular and Molecular Neuroscience; Neurology (clinical); Physiology.

Pp. 354-361

Pain perception during electrodiagnostic studies and the impact of learners

Freddy Paiz; Gyl Midroni; Charles D. KassardjianORCID

Palabras clave: Physiology (medical); Cellular and Molecular Neuroscience; Neurology (clinical); Physiology.

Pp. 621-624

Traumatic injury to peripheral nerves

Lawrence R. Robinson

<jats:title>Abstract</jats:title><jats:p>This article reviews the epidemiology, classification, localization, prognosis, and mechanisms of recovery of traumatic peripheral nerve injuries (PNIs). Electrodiagnostic (EDx) assessments are critical components of treating patients with PNIs. In particular, motor and sensory nerve conduction studies, needle electromyography, and other electrophysiological methods are useful for localizing peripheral nerve injuries, detecting and quantifying the degree of axon loss, and contributing toward treatment decisions as well as prognostication. It is critical that EDx medical consultants are aware of the timing of these changes as well as limitations in interpretations. Mechanisms of recovery may include recovery from conduction block, muscle fiber hypertrophy, distal axonal sprouting, and axon regrowth from the site of injury. Motor recovery generally reaches a plateau at 18 to 24 months postinjury. When patients have complete or severe nerve injuries they should be referred to surgical colleagues early after injury, as outcomes are best when nerve transfers are performed within the first 3 to 6 months after onset.</jats:p>

Pp. 661-670

Imaging of neuralgic amyotrophy in the acute phase

Paolo RipellinoORCID; Zsuzsanna Arányi; Nens van Alfen; Elisa Ventura; Anne‐Kathrin Peyer; Alessandro Cianfoni; Claudio Gobbi; Emily Pedrick; Darryl Brett SneagORCID

Palabras clave: Physiology (medical); Cellular and Molecular Neuroscience; Neurology (clinical); Physiology.

Pp. 709-714

Necrotizing myopathy with elevated anti‐HMGCR antibodies following exposure to the supplement Bacopa

Amanda M. YaworskiORCID; Michael Blyumin; Tiffany Chang; Andrew L. Mammen; Maxwell GreeneORCID

Pp. No disponible

Electrosonomyography: Avoiding the scalpel in traumatic nerve injury?

Neil G. SimonORCID; Andrew Hannaford

Palabras clave: Physiology (medical); Cellular and Molecular Neuroscience; Neurology (clinical); Physiology.

Pp. 189-190