Catálogo de publicaciones - revistas

<jats:title>Carboxysomes in a Row</jats:title> <jats:p> The carboxysome is an organelle-like proteinaceous microcompartment that sequesters the enzymes of carbon fixation from the rest of the cytoplasm in cyanobacteria. Cyanobacterial carbon fixation is a major component of the global carbon cycle. <jats:bold> Savage <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1258" related-article-type="in-this-issue" vol="327" xlink:href="10.1126/science.1186090">1258</jats:related-article> ) now show that carboxysomes are linearly arranged within the cytoplasm in a process that involves the bacterial cytoskeleton. This arrangement is important in carboxysome partitioning during cell division. When carboxysome partitioning is disrupted by interfering with the bacterial cytoskeleton, carbon fixation is impaired. </jats:p>

<jats:title>Corpse-Sorting Machinery</jats:title> <jats:p> Phagocytosis of apoptotic cells is an integral part of the cell death program and plays critical roles in tissue remodeling, suppression of inflammation, and regulation of immune responses. The clearance of cell corpses requires their engulfment and subsequent degradation by phagocytic cells. During this process, receptors of the CED-1 family play a central role in recognizing cell corpses, transducing engulfment signals, and initiating the maturation of phagosomes containing apoptotic cell corpses. Retromer is a multisubunit protein complex conserved from yeast to mammals that mediates retrograde transport of transmembrane cargo from the endosome to the trans-Golgi network. Failure in recycling these proteins leads to their delivery to lysosomes where they are degraded. <jats:bold> Chen <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1261" related-article-type="in-this-issue" vol="327" xlink:href="10.1126/science.1184840">1261</jats:related-article> , published online 4 February) report that the <jats:italic>Caenorhabditis elegans</jats:italic> retromer complex is essential for the phagocytosis of CED-1 and thus for the clearance of apoptotic cells. </jats:p>

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