Catálogo de publicaciones - revistas

<jats:p>Do ancient microbial irritants offer early life protection against diabetes?</jats:p>

<jats:p>Mycobiota modulate immunity and behavior</jats:p>

<jats:p>Host-derived metabolite trains the microbiota to develop colonization resistance</jats:p>

<jats:p> Highlights from the <jats:italic>Science</jats:italic> family of journals </jats:p>

<jats:p>Editors’ selections from the current scientific literature</jats:p>

<jats:p>Despite huge potential, automation of synthetic chemistry has only made incremental progress over the past few decades. We present an automatically executable chemical reaction database of 100 molecules representative of the range of reactions found in contemporary organic synthesis. These reactions include transition metal–catalyzed coupling reactions, heterocycle formations, functional group interconversions, and multicomponent reactions. The chemical reaction codes or χDLs for the reactions have been stored in a database for version control, validation, collaboration, and data mining. Of these syntheses, more than 50 entries from the database have been downloaded and robotically run in seven modular ChemPU’s with yields and purities comparable to those achieved by an expert chemist. We also demonstrate the automatic purification of a range of compounds using a chromatography module seamlessly coupled to the platform and programmed with the same language.</jats:p>

<jats:p>Helical alignments within the heart’s musculature have been speculated to be important in achieving physiological pumping efficiencies. Testing this possibility is difficult, however, because it is challenging to reproduce the fine spatial features and complex structures of the heart’s musculature using current techniques. Here we report focused rotary jet spinning (FRJS), an additive manufacturing approach that enables rapid fabrication of micro/nanofiber scaffolds with programmable alignments in three-dimensional geometries. Seeding these scaffolds with cardiomyocytes enabled the biofabrication of tissue-engineered ventricles, with helically aligned models displaying more uniform deformations, greater apical shortening, and increased ejection fractions compared with circumferential alignments. The ability of FRJS to control fiber arrangements in three dimensions offers a streamlined approach to fabricating tissues and organs, with this work demonstrating how helical architectures contribute to cardiac performance.</jats:p>

<jats:p>Two models describe solvent transport through swollen, nonporous membranes. The pore-flow model, based on fluid mechanics, works for porous membranes, whereas the solution-diffusion model invokes molecular diffusion to treat nonporous membranes. Both approaches make valid arguments for swollen polymer membranes, but they disagree in their predictions of intramembrane pressure and concentration profiles. Using a fluid-solid model that treats the solvent and membrane matrix as separate phases, we show both classical models to be valid, to represent complementary approaches to the same phenomenon, and to make identical predictions. The fluid-solid model clarifies recent reverse osmosis measurements; provides a predictive and mechanistic basis for empirical high-pressure limiting flux phenomena, in quantitative agreement with classic measurements; and gives a framework to treat nonporous but mechanically heterogeneous membrane materials.</jats:p>

<jats:p>Gender-targeted police reforms are frequently proposed to tackle the global problem of rising yet under-reported gender-based violence (GBV)—but with mixed and often disappointing results. We explore this issue in India, a country with alarming rates of GBV and limited police capacity, by studying the impact of Women’s Help Desks (WHDs): dedicated spaces for women in local police stations, staffed by trained officers. Drawing on the largest randomized controlled trial of a police reform to date (180 police stations serving 23.4 million people), we find that officers in stations with WHDs are more likely to register cases of GBV, particularly where female officers run the desks. This suggests that even in resource-constrained and patriarchal environments, police responsiveness can be improved by focusing and mainstreaming attention to women’s cases and by greater gender representation within the police.</jats:p>