Catálogo de publicaciones - revistas

<jats:p>In the forebrain, ventrally derived oligodendrocyte precursor cells (vOPCs) travel tangentially toward the cortex together with cortical interneurons. Here, we tested in the mouse whether these populations interact during embryogenesis while migrating. By coupling histological analysis of genetic models with live imaging, we show that although they are both attracted by the chemokine Cxcl12, vOPCs and cortical interneurons occupy mutually exclusive forebrain territories enriched in this chemokine. Moreover, first-wave vOPC depletion selectively disrupts the migration and distribution of cortical interneurons. At the cellular level, we found that by promoting unidirectional contact repulsion, first-wave vOPCs steered the migration of cortical interneurons away from the blood vessels to which they were both attracted, thereby allowing interneurons to reach their proper cortical territories.</jats:p>

<jats:p>The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal tyrosine of α-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The vasohibin–small vasohibin-binding protein (SVBP) complex underlies much, but not all, detyrosination. We used haploid genetic screens to identify an unannotated protein, microtubule associated tyrosine carboxypeptidase (MATCAP), as a remaining detyrosinating enzyme. X-ray crystallography and cryo–electron microscopy structures established MATCAP’s cleaving mechanism, substrate specificity, and microtubule recognition. Paradoxically, whereas abrogation of tyrosine religation is lethal in mice, codeletion of MATCAP and SVBP is not. Although viable, defective detyrosination caused microcephaly, associated with proliferative defects during neurogenesis, and abnormal behavior. Thus, MATCAP is a missing component of the detyrosination-tyrosination cycle, revealing the importance of this modification in brain formation.</jats:p>

<jats:p> Topological quantum chemistry and symmetry-based indicators have facilitated large-scale searches for materials with topological properties at the Fermi energy ( <jats:italic>E</jats:italic> <jats:sub>F</jats:sub> ). We report the implementation of a publicly accessible catalog of stable and fragile topology in all of the bands both at and away from <jats:italic>E</jats:italic> <jats:sub>F</jats:sub> in the 96,196 processable entries in the Inorganic Crystal Structure Database. Our calculations, which represent the completion of the symmetry-indicated band topology of known nonmagnetic materials, have enabled the discovery of repeat-topological and supertopological materials, including rhombohedral bismuth and Bi <jats:sub>2</jats:sub> Mg <jats:sub>3</jats:sub> . We find that 52.65% of all materials are topological at <jats:italic>E</jats:italic> <jats:sub>F</jats:sub> , roughly two-thirds of bands across all materials exhibit symmetry-indicated stable topology, and 87.99% of all materials contain at least one stable or fragile topological band. </jats:p>

<jats:p> A recently leaked draft opinion indicated that the US Supreme Court is prepared to overturn <jats:italic>Roe v. Wade</jats:italic> as early as next month in the matter of <jats:italic>Dobbs v. Jackson Women’s Health Organization</jats:italic> . In doing so, the Justices won’t just be disregarding decades of precedent. They’ll also be disregarding ample evidence of abortion’s positive impact on patients’ health and well-being. </jats:p>

<jats:p>Researchers who pivoted from distant disciplines produced lower impact work, study finds</jats:p>

<jats:p>A U.S. government contest has 10 companies competing to make better face coverings</jats:p>

<jats:p>Scene resembles earlier image from a distant galaxy, as Einstein’s theory predicts</jats:p>

<jats:p>Breakdown of “biocrusts” allows wind to attack dryland soils</jats:p>

<jats:p>Institutions now legally required to inform agency if grantees are “disciplined” for workplace misbehavior</jats:p>