Catálogo de publicaciones - revistas

<jats:p>Although behavioral interventions are designed to seize attention, little consideration has been given to the costs of doing so. We estimated these costs in the context of a safety campaign that, to encourage safe driving, displays traffic fatality counts on highway dynamic message signs for 1 week each month. We found that crashes increase statewide during campaign weeks, which is inconsistent with any benefits. Furthermore, these effects do not persist beyond campaign weeks. Our results show that behavioral interventions, particularly negatively framed ones, can be too salient, crowding out more important considerations and causing interventions to backfire—with costly consequences.</jats:p>

<jats:p>The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (Omicron) variant and its resistance to neutralization by vaccinee and convalescent sera are driving a search for monoclonal antibodies with potent neutralization. To provide insight into effective neutralization, we determined cryo–electron microscopy structures and evaluated receptor binding domain (RBD) antibodies for their ability to bind and neutralize B.1.1.529. Mutations altered 16% of the B.1.1.529 RBD surface, clustered on an RBD ridge overlapping the angiotensin-converting enzyme 2 (ACE2)–binding surface and reduced binding of most antibodies. Substantial inhibitory activity was retained by select monoclonal antibodies—including A23-58.1, B1-182.1, COV2-2196, S2E12, A19-46.1, S309, and LY-CoV1404—that accommodated these changes and neutralized B.1.1.529. We identified combinations of antibodies with synergistic neutralization. The analysis revealed structural mechanisms for maintenance of potent neutralization against emerging variants.</jats:p>

<jats:p>Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses, revealing mutational signatures, imprints of DNA damage, and repair processes that have arisen in each patient’s cancer. We performed mutational signature analyses on 12,222 whole-genome–sequenced tumor-normal matched pairs from patients recruited via the UK National Health Service (NHS). We contrasted our results with two independent cancer WGS datasets—from the International Cancer Genome Consortium (ICGC) and the Hartwig Medical Foundation (HMF)—involving 18,640 whole-genome–sequenced cancers in total. Our analyses add 40 single and 18 double substitution signatures to the current mutational signature tally. We show for each organ that cancers have a limited number of common signatures and a long tail of rare signatures, and we provide a practical solution for applying this concept of common versus rare signatures to future analyses.</jats:p>

<jats:p>Flat optics has emerged as a key player in the area of structured light and its applications, owing to its subwavelength resolution, ease of integration, and compact footprint. Although its first generation has revolutionized conventional lenses and enabled anomalous refraction, new classes of meta-optics can now shape light and dark features of an optical field with an unprecedented level of complexity and multifunctionality. Here, we review these efforts with a focus on metasurfaces that use different properties of input light—angle of incidence and direction, polarization, phase distribution, wavelength, and nonlinear behavior—as optical knobs for tuning the output response. We discuss ongoing advances in this area as well as future challenges and prospects. These recent developments indicate that optically tunable flat optics is poised to advance adaptive camera systems, microscopes, holograms, and portable and wearable devices and may suggest new possibilities in optical communications and sensing.</jats:p>

<jats:p>As the world becomes increasingly dependent on satellites and other space technology, new participants from every global region are joining the “space club” to reap the benefits—expanding communication and navigation capabilities; guiding policies with Earth observations; developing economies through growth in space ventures; and deepening our understanding of the cosmos through exploration. Consequently, countries are focusing on job opportunities, competitiveness, national security, and on having a voice in the global governance of space activities. Africa not only has a growing interest in space, but African countries are realizing that there is strength in pooling their resources and efforts to grow the continent’s outer space enterprise.</jats:p>

<jats:p>Influential survey recommends $4.2 billion flagship mission to the ice giant Influential survey</jats:p>

<jats:p>Still not fully prepared for living with the virus, the government is sticking to “zero COVID”</jats:p>

<jats:p>Study suggests feathers arose—and were used for display—well before reign of dinosaurs</jats:p>