Catálogo de publicaciones - revistas

<jats:p>Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanisms and therapeutic strategies requires a deeper knowledge of cerebrovascular cells in humans. We profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular cell diversity. By leveraging this reference, we investigated cellular and molecular perturbations in brain arteriovenous malformations, which are a leading cause of stroke in young people, and identified pathologic endothelial transformations with abnormal vascular patterning and the ontology of vascularly derived inflammation. We illustrate the interplay between vascular and immune cells that contributes to brain hemorrhage and catalog opportunities for targeting angiogenic and inflammatory programs in vascular malformations.</jats:p>

<jats:p> For more than 100 years, the fruit fly <jats:italic>Drosophila melanogaster</jats:italic> has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula <jats:italic>Drosophilae</jats:italic> , that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to &gt;250 distinct cell types. We provide an in-depth analysis of cell type–related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the <jats:italic>Drosophila</jats:italic> community and serves as a reference to study genetic perturbations and disease models at single-cell resolution. </jats:p>

<jats:p>Land degradation reduces soil functioning and, consequently, the services that soil provides. Soil hydrological functions are critical to combat soil degradation and promote soil restoration. Soil microorganisms affect soil hydrology, but the role of soil microbiota in forming and sustaining soil is not well explored. Case studies indicate the potential of soil microorganisms as game-changers in restoring soil functions. We review the state of the art of microorganism use in land restoration technology, the groups of microorganisms with the greatest potential for soil restoration, knowledge of the effect of microorganisms on soil physical properties, and proposed strategies for the long-term restoration of degraded lands. We also emphasize the need to advance the emerging research field of biophysical landscape interactions to support soil-plant ecosystem restoration practices.</jats:p>

<jats:p>William Shockley Jr. of Stanford University was an American physicist who jointly won the 1956 Nobel Prize in Physics for his role in inventing the transistor. Modern computing and communications would have been unthinkable without Shockley’s work. But the Nobel laureate was also a proponent of eugenics and firmly committed to the racial inferiority of Black people. Shockley was not just a physicist who held racist views. He was part of a wider academic system that then, and now, perpetuates racial inequality. The persistence of this biased ecosystem means that dismantling it will require unrelenting tenacity by all of academia.</jats:p>

<jats:p>It has been a rough 2 weeks for the US science community. After 4 years of bludgeoning by the Trump administration, hope resurged a year ago as a new White House promised to value science. But there have been missteps, the most recent taking place on the heels of another blunder that many saw coming. Eric Lander, who just stepped down as President Biden’s science adviser and director of the Office of Science and Technology Policy (OSTP), was a prominent research figure with a well-known record of bullying and callous actions. With the notable exception of the 500 Women Scientists organization, the scientific community was embarrassingly silent about Lander’s nomination. Not surprisingly, he is out of the White House because of the same behavioral issues. And yet, in another tone deaf move, the administration just named Francis Collins, the recently retired director of the National Institutes of Health (NIH), as Lander’s interim replacement as science adviser while asking Alondra Nelson, the OSTP’s deputy director for science and society and an experienced administrator and scholar, to temporarily direct OSTP. Apparently, Biden doesn’t think Nelson is capable of doing both jobs. I disagree and am not staying silent this time.</jats:p>

<jats:p>As Ukrainian researchers hunker down or flee, backlash against Russian science builds</jats:p>

<jats:p>ITER must meet safety concerns before welding giant tokamak sections</jats:p>

<jats:p>“Eye-opening” discovery challenges evolutionary thinking on microbes</jats:p>

<jats:p>Justice Department promises tighter focus on preventing espionage and no profiling of Chinese academics</jats:p>