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Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde mar. 1997 / hasta dic. 2023	Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

1880-

Cobertura temática

Ciencias naturales

Tabla de contenidos

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doi: 10.1126/science.1173164

Genome-Wide RNAi Screen Identifies Genes Involved in Intestinal Pathogenic Bacterial Infection

Shane J. F. Cronin; Nadine T. Nehme; Stefanie Limmer; Samuel Liegeois; J. Andrew Pospisilik; Daniel Schramek; Andreas Leibbrandt; Ricardo de Matos Simoes; Susanne Gruber; Urszula Puc; Ingo Ebersberger; Tamara Zoranovic; G. Gregory Neely; Arndt von Haeseler; Dominique Ferrandon; Josef M. Penninger

<jats:title>Innate Immunity in the Fly Gut</jats:title> <jats:p> <jats:italic>Drosophila melanogaster</jats:italic> is an important model system to study innate immunity, being both easy to manipulate and lacking an adaptive immune system. In order to identify genes that regulate innate immunity, <jats:bold> Cronin <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="340" related-article-type="in-this-issue" vol="325" xlink:href="10.1126/science.1173164">340</jats:related-article> ; published online 11 June) performed an RNA interference screen on flies infected with the oral bacterial pathogen, <jats:italic>Serratia marcescens</jats:italic> . Genes involved in intestinal immunity and regulation of hemocytes, macrophage-like cells critical for phagocytosis and killing of the bacteria, were identified. Several hundred genes conferred either enhanced susceptibility or resistance to bacterial infection. Furthermore, the JAK/STAT signaling pathway was activated in intestinal stem cells after bacterial infection, resulting in enhanced susceptibility to infection, most likely through regulation of intestinal stem cell homeostasis. </jats:p>

Palabras clave: Multidisciplinary.

Pp. 340-343

doi: 10.1126/science.325_344b

Science Podcast

Robert Frederick (eds.)

<jats:p>The show includes the dynamics of rotavirus epidemics, how tiger moths jam bat sonar, a look at NIH's new director, and more.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 344-344

doi: 10.1126/science.325_344a

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 344-344

doi: 10.1126/science.325_366a