Catálogo de publicaciones - libros

Improving the treatment of pancreatic cancer is a challenge. Whenever possible, patients should be enrolled in investigational studies that evaluate novel therapies. Outside of a clinical trial, postoperative chemoradiation is the current standard adjuvant treatment after pancreaticoduodenectomy in the United States, but results from all randomized trials indicate significant rates of local tumor recurrence. For locally advanced disease, improving local tumor control rates is an important goal as well. In both cases, patients probably benefit from gemcitabine-based chemotherapy as well as chemoradiation. A strategy that incorporates both probably takes advantage of the best-available established therapies. The incorporation of molecularly targeted therapy with well-tolerated chemoradiation and chemotherapy regimens is a promising approach that addresses the limitations of conventional therapy without introducing unacceptable toxicity. Fortunately, investigators have placed more emphasis on pancreatic cancer in recent years than in the past, and many more clinical trials evaluating novel radiosensitizers are available to patients. Enrollment of patients in these studies is critical to the improvement of outcome in this disease.

Delegation of authorities is a common practice in various organizations. The way delegation is performed can be quite complicated. To capture possible delegation structures, the concept of is proposed, so that anyone can be convinced of who obtained delegation from whom in order to produce the final proxy signature. In this paper, we consider the delegation network for identity-based (ID-based) scenario. Since the public key is just a string denoting the user’s identity, certificate management is simplified. Proxy signature schemes have been devised to delegate signing authorities. We show that a trivial attempt of extending an existing ID-based proxy signature may result in an insecure scheme. After that we propose a building block of our ID-based delegation network, which is an ID-based proxy signature supporting batch verifications. Our proposed ID-based delegation network is flexible in the sense that the whole delegation network does not need to be known in advance. Our proposal is provably secure under the random oracle model.