Catálogo de publicaciones - libros

Although numbers of promising agents to control abnormal prion protein in vitro or in vivo, none of the sufficiently effective and safe agent has been discovered for patients with Creutzfeldt-Jakob disease (CJD). Quinacrine and pentosan polysulfate (PPS) have been reported as possible useful agents for treatment of CJD. We administrated PPS oral treatment for eight patients with CJD, then evaluated clinical effects of oral PPS. Oral PPS were not effective in seven cases except “response to person” and “frequency of myoclonus” in some patients. One patient was evaluated to be effective in “30m walking time” and in improvement of “preservation of words”. In this case, these effects were transient.