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Pharmacovigilance in the European Union: Practical Implementation across Member States

Resumen/Descripción – provisto por la editorial

No disponible.

Palabras clave – provistas por la editorial

Comparative Politics; Political Economy; European Union Politics; Drug Safety and Pharmacovigilance

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Información

Tipo de recurso:

libros

ISBN impreso

978-3-319-41284-9

ISBN electrónico

978-3-319-41285-6

Editor responsable

Springer Nature

País de edición

Reino Unido

Fecha de publicación

Tabla de contenidos

Introduction to Part II

Gerard ’t Hooft

A general introduction is presented to the more technical Part II of this book. It is explained how we arrive at our choice of notation, how we attempt and sometimes fail to make the notation completely consistent and straightforward throughout the book.

Part II - Calculation Techniques | Pp. 121-127

More on Cogwheels

Gerard ’t Hooft

The prototype of the simplest periodic deterministic systems is a model whose states move on a circle. The prototype of the quantum mechanical periodic system is the harmonic oscillator. In line with the philosophy on which this book it based, these two models can be mapped one onto the other. However, we need an intermediate case: the harmonic . We illustrate the use of the group for this model, and we explain how to take the ‘continuum limit’.

Part II - Calculation Techniques | Pp. 129-134

The Continuum Limit of Cogwheels, Harmonic Rotators and Oscillators

Gerard ’t Hooft

It is shown how the mathematics has to be set up that is needed to relate classical and quantum mechanical periodic worlds, in the case both contain large numbers of states, while, eventually, we wish to introduce perturbations and interactions.

Part II - Calculation Techniques | Pp. 135-139

Locality

Gerard ’t Hooft

The usual ‘proofs’ that deterministic hidden variable models for quantum mechanics cannot be completely local, are based on rather indirect arguments, using thought experiments, free will, and the like. In this chapter we show how difficulties emerge when we wish to construct mathematical models. We also show how, in principle, the problem can be addressed at the level of model building.

Part II - Calculation Techniques | Pp. 141-145

Fermions

Gerard ’t Hooft

Classical theories starting with continuous degrees of freedom will typically generate bosonic quantum objects; fermionic quantum objects in turn, arise when a classical system contains discrete degrees of freedom—typically: flip-flops. Here, we explain how anti-commuting operators enter the scene, and illustrate the situation using an elegant model: the idealized notion of a ‘neutrino’. What do neutrinos have in common with infinite, at sheets, and where does spin come from? The associated mathematical tool kit is quite delicate.

Part II - Calculation Techniques | Pp. 147-167

Theory

Gerard ’t Hooft

What is badly needed is an elegant mathematical scheme that replaces position and momentum operators and by discrete, commuting counterparts,  and , in such a way that mappings can be defined between conventional, quantum mechanical systems and deterministic, discrete systems. Here the foundations for such a scheme is suggested. An essential role is played by the Jacobi theta functions.

Part II - Calculation Techniques | Pp. 169-179

Models in Two Space–Time Dimensions Without Interactions

Gerard ’t Hooft

Sooner or later, we shall have to contemplate multi-particle systems and quantized field theories. These naturally arise whenever quantum mechanics confronts Einstein’s Special Relativity. The prototype is the theory of bosons in one space-, one time dimension. First, we consider the massless, non-interacting case. This allows for a mapping onto a deterministic system: the (continuum limit of a) cellular automaton. Now, both classically and quantum mechanically, these models are trivial and featureless, so we have to ask how mass terms and interactions are to be introduced, and how to go from 1 to 3 space-like dimensions (if not more).

This is where the mathematics becomes hard, but there is something else we can do: (-) is based on a two-dimensional world: the string world sheet. At first sight, our results may seem to be spectacular: , a dimensional lattice with lattice links of length . As yet, however, this only seems to apply to the bulk behavior of strings, not their interaction mechanism, which, in this formalism, is quite complex.

Knowing that strings also generate the gravitational force, this should not have come as a surprise.

Part II - Calculation Techniques | Pp. 181-214

Symmetries

Gerard ’t Hooft

In classical, deterministic systems, we may have classical symmetries, transforming ontological states into other ontological states. In line with our general philosophy, we now extend the group of symmetries using quantum symmetries, where ontological states are compared with superimposed states. The groups of symmetry transformations obtained this way may become much larger than that of the classical symmetries. Some of the mathematical procedures, borrowed from ‘ordinary’ quantum mechanics, are explained.

Part II - Calculation Techniques | Pp. 215-226

The Discretized Hamiltonian Formalism in Theory

Gerard ’t Hooft

In standard quantum mechanics, the construction of the Schrödinger equation requires a Hamiltonian operator, which must obey some important restrictions. Most of our deterministic models are, to some extent, discrete. How do we carry over the standard Hamiltonian formalism to a discretized world? As in the continuum case, we may assume that conjugate pairs () can be defined, but now and are integers. How can a Hamiltonian function be used to define an evolution law?

Part II - Calculation Techniques | Pp. 227-243

Quantum Field Theory

Gerard ’t Hooft

Since the finiteness of the speed of light, and other considerations of special relativity, play such an important role in arguments concerning the interpretation of quantum mechanics, a good understanding of quantum field theory is a prerequisite. In this chapter, a brief summary is presented of what Quantum Field Theory is, and what one can conclude from it. The fundamental fields are bosonic fields, accounting for fundamental particles with spin 0 and 1, and fermionic fields describing fundamental particles with spin . Within the framework of Quantum Field Theory, there are no conflicts between quantum mechanics and locality, causality, and positivity of the energy, but there seems to be no ‘underlying real world’. We do note the importance of correlations, even in the vacuum state.

Part II - Calculation Techniques | Pp. 245-260