Catálogo de publicaciones - revistas

<jats:title>Abstract</jats:title> <jats:p>High rate of bone grafting surgeries emphasizes the need for optimal bone substitutes. Biomaterials mimicking the interconnected porous structure of the original bone with osteoconductive and osteoinductive capabilities have long been considered. Hydroxyapatite (HA), as the main inorganic part of natural bone, has exhibited excellent regenerative properties in bone tissue engineering. This manuscript reviews the HA extraction methods from bovine bone, as one of the principal biosources. Essential points in the extraction process have also been highlighted. Characterization of the produced HA through gold standard methods such as XRD, FTIR, electron microscopies (SEM and TEM), mechanical/thermodynamic tests, and bioactivity analysis has been explained in detail. Finally, future perspectives for development of HA constructs are mentioned.</jats:p>

<jats:title>Abstract</jats:title> <jats:p> <jats:italic>Objective</jats:italic>. Vertebrae models from computer tomographic (CT) imaging are extensively used in image-guided surgical systems to deliver percutaneous orthopaedic operations with minimum risks, but patients may be exposed to excess radiation from the pre-operative CT scans. Generating vertebrae models from intra-operative x-rays for image-guided systems can reduce radiation exposure to the patient, and the surgeons can acquire the vertebrae’s relative positions during the operation; therefore, we proposed a lumbar vertebrae reconstruction method from biplanar x-rays. <jats:italic>Approach</jats:italic>. Non-stereo-corresponding vertebral landmarks on x-rays were identified as targets for deforming a set of template vertebrae; the deformation was formulated as a minimisation problem, and was solved using the augmented Lagrangian method. Mean surface errors between the models reconstructed using the proposed method and CT scans were measured to evaluate the reconstruction accuracy. <jats:italic>Main results</jats:italic>. The evaluation yielded mean errors of 1.27 mm and 1.50 mm in <jats:italic>in vitro</jats:italic> experiments on normal vertebrae and pathological vertebrae, respectively; the outcomes were comparable to other template-based methods. <jats:italic>Significance</jats:italic>. The proposed method is a viable alternative to provide digital lumbar to be used in image-guided systems, where the models can be used as a visual reference in surgical planning and image-guided applications in operations where the reconstruction error is within the allowable surgical error.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>Natural products from plants, such as flavonoids, arouse immense interest in medicine because of the therapeutic and many other bioactive properties. The molecular docking is a very useful method to screen the molecules based on their free binding energies and give important structural suggestions about how molecules might activate or inhibit the target receptor by comparing reference molecules. Alliin and Allicin differ from many other flavonoids because of containing no benzene rings and having nitrogen and sulfur atoms in their structure. In this study Alliin and Allicin affinity on AMPA, NMDA and GABA-A receptors were evaluated in the central nervous system by using the molecular docking method. Both Alliin and Allicin indicated no inhibitory effects. However Alliin showed significant selectivity to human AMPA receptor (3RN8) as an excitatory. The binding energy of glutamate to 3RN8 was −6.61 kcal mol<jats:sup>−1</jats:sup>, while the binding energy of Allin was −8.08 kcal mol<jats:sup>−1</jats:sup>. Furthermore Alliin’s affinity to the other AMPA and NMDA receptors is quite satisfactory compared to the reference molecule glutamate. In conclusion based on the molecular docking study, Alliin can be useful for synaptic plasticity studies whereas might be enhance seizure activity because of the increased permeability to cations. It also can be beneficial to improve learning and memory and can be used as a supportive product to the hypofunction of NMDA associated problems.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>A malignant tumor is an uncontrolled growth of tissues receiving energy in form of the nutrients provided by the microvascular networks. It is proposed that the supplied energy to a tumor is used for three purposes: the creation of new cells, maintenance of tumor cells, and tumor volume expansion by overcoming external pressure. A mathematical model studying the effects of energy required for maintenance and overcoming external pressure, the energy required creating a single cell, death rate, and tumor cell density on tumor development has been formulated. Including a term, residual energy for tumor growth in the tumor growth equation, the well-known logistic equation has been re-derived for tumors. Analytical solutions have been developed, and numerical analysis for the growth in brain tumors with the variation of parameters related to energy supply, the energy required for maintenance, and expansion of tumor has been performed. Expressions for the tumor growth rate(r) and carrying capacity(C) of the tumor are formulated in terms of the parameters used in the model. The range of ‘r’, estimated using our model is found within the ranges of tumor growth rates in gliomas reported by the other researchers. Selecting the model parameters precisely for a particular individual, the tumor growth rate and carrying capacity could be estimated accurately. Our study indicates that the actual growth rate and carrying capacity of a tumor reduce and tumor saturation time increases with the increase of death rate, the energy required for a single cell division, and energy requirement for the tumor cell maintenance.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>This study was devoted to determining the unwanted dose due to scattered photons to the out-of-field organs and subsequently estimate the risk of secondary cancers in the patients undergoing pelvic radiotherapy. A typical 18 MV Medical Linear Accelerator (Varian Clinac 2100 C/D) was modeled using MCNPX<jats:sup>®</jats:sup> code to simulate pelvic radiotherapy with four treatment fields: anterior-posterior, posterior-anterior, right lateral, left lateral. Dose evaluation was performed inside Medical Internal Radiation Dose (MIRD) revised female phantom. The average photon equivalent dose in out-of-field organs is 8.53 mSv Gy<jats:sup>−1</jats:sup>, ranging from 0.17 to 72.11 mSv Gy<jats:sup>−1</jats:sup>, respectively, for the organs far from the Planning Treatment Volume (Brain) and those close to the treatment field (Colon). Evidence showed that colon with 4.3049% and thyroid with 0.0020% have the highest and lowest risk of secondary cancer, respectively. Accordingly, this study introduced the colon as an organ with a high risk of secondary cancer which should be paid more attention in the follow-up of patients undergoing pelvic radiotherapy. The authors believe that this simple Monte Carlo (MC) model can be also used in other radiotherapy plans and mathematical phantoms with different ages (from childhood to adults) to estimate the out-of-field dose. The extractable information by this simple MC model can be also employed for providing libraries for user-friendly applications (e.g. ‘.apk’) which in turn increase the public knowledge about fatal cancer risk after radiotherapy and subsequently decrease the concerns in this regard among the public.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>The dose rate distributions delivered to 55 prostate and head &amp; neck (H&amp;N) cancer patients treated with a helical TomoTherapy (HT) system were resolved and assessed with regard to pitch and field width defined during treatment planning. Statistical analysis of the studied cases showed that the median treatment delivery time was 4.4 min and 6.3 min for the prostate and H&amp;N cases, respectively. Dose rate volume histogram data for the studied cases showed that the 25% and 12% of the volume of the planning target volumes of the prostate and H&amp;N cases are irradiated with a dose rate of greater or equal to 1 Gy min<jats:sup>−1</jats:sup>. Quartile dose rate (QDR) data confirmed that in HT, where the target is irradiated in slices, most of the dose is delivered to each voxel of the target when it travels within the beam. Analysis of the planning data from all cases showed that this lasts for 68 s (median value). QDRs results showed that using the 2.5 cm field width, 75% of the prescribed dose is delivered to target voxels with a median dose rate of at least 3.2 Gy min<jats:sup>−1</jats:sup> and 4.5 Gy min<jats:sup>−1</jats:sup>, for the prostate and H&amp;N cases, respectively. Systematically higher dose rates were observed for the H&amp;N cases due to the shallower depths of the lesions in this anatomical site. Delivered dose rates were also found to increase with field width and pitch setting, due to the higher output of the system which, in general, results in accordingly decreased total treatment time. The biological effect of the dose rate findings of this work needs to be further investigated using in-vitro studies and clinical treatment data.</jats:p>

<jats:title>Abstract</jats:title> <jats:p>3D imaging modalities such as computed tomography and digital tomosynthesis typically scan the patient from different angles with a lengthy mechanical movement of a single x-ray tube. Therefore, millions of 3D scans per year require expensive mechanisms to support a heavy x-ray source and have to compensate for machine vibrations and patient movements. However, recent developments in cold-cathode field emission technology allow the creation of compact, stationary arrays of emitters. Adaptix Ltd has developed a novel, low-cost, square array of such emitters and demonstrated 3D digital tomosynthesis of human extremities and small animals. The use of cold-cathode field emitters also makes the system compact and lightweight. This paper presents Monte Carlo simulations of a concept upgrade of the Adaptix system from the current 60 kVp to 90 kVp and 120 kVp which are better suited for chest imaging. Between 90 kVp and 120 kVp, 3D image quality appears insensitive to voltage and at 90 kVp the photon yield is reduced by 40%–50% while effective dose declines by 14%. A square array of emitters can adequately illuminate a subject for tomosynthesis from a shorter source-to-image distance, thereby reducing the required input power, and offsetting the 28%–50% more input power that is required for operation at 90 kVp. This modelling suggests that lightweight, stationary cold-cathode x-ray source arrays could be used for chest tomosynthesis at a lower voltage, with less dose and without sacrificing image quality. This will reduce weight, size and cost, enabling 3D imaging to be brought to the bedside.</jats:p>